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Aging clinical trials at UC Health
5 in progress, 4 open to eligible people

  • Aging Mastery Program® (AMP) Evaluation

    open to eligible people ages 50-100

    The Aging Mastery Program® (AMP) is designed to inform, encourage, and support older adults as they take steps to improve their lives and stay engaged in their communities. The program incorporates evidence-informed materials, expert speakers, group discussion, peer support, and small rewards to give participants the skills and tools they need to achieve measurable improvements in managing their health, remaining economically secure, and contributing actively to society. L.A. CAPRA in partnership with the National Council on Aging, City of Los Angeles and the Los Angeles County Department of Aging will evaluate the effectiveness of the AMP program across 5 community-based senior sites. The overall objective of the proposed study is to evaluate the effectiveness of AMP program on improving the health and well-being of older adults using a randomized wait-list controlled trial.

    at UCLA

  • Enhancing Memory Consolidation in Older Adults

    open to eligible people ages 60-75

    The purpose of this research study is to understand the neural mechanisms underlying long-term memory formation in older adults. Both sleep and memory decrease with age. The investigators are interested in discovering whether these two biological changes are related. This study is specifically focused on understanding what are the critical components of sleep that facilitate memory formation and are they impaired in older adults. The investigators will be using the hypnotic zolpidem, a sleep drug that has been shown to increase a specific aspect of sleep that have been shown to correlate with memory improvement in young adults. The Food and Drug Administration (FDA) have approved zolpidem for use in certain sleep disorders, specifically in the treatment of sleeplessness (i.e., insomnia). In the current study, the investigators will examine whether zolpidem (5mg), compared with placebo, increases memory-related sleep events in older adults and test the impact of these drug-related sleep changes on post-sleep memory recall. This is a research study because the investigators are using pharmacological interventions to investigate our hypotheses about memory consolidation. The investigators are not studying the efficacy of zolpidem to treat conditions for which the FDA has already approved it.

    at UC Irvine

  • Independent Walking for Brain Health

    open to eligible people ages 65-80

    Physical activity interventions with older adults can improve brain health; however most interventions have been performed in gym-like settings that reach a small sector of the senior population. Since not everyone can access a gym, it is important to study whether brisk walking in real world environments can also help brain health. This study will use mobile health devices to help older adults independently walk for brain health, thus representing a critical step towards the dissemination of physical activity intervention programs aimed at preserving cognitive function in aging.

    at UCSD

  • Training to Enhance Cognition in Older Adults

    open to eligible people ages 60-80

    This is a planning project with a clinical trial pilot to prepare for a larger fully powered clinical trial. Goals of this pilot project are: to identify and address any modifications of the games required for adaptation to diminished sensory abilities; to optimize training dosage and test timing of retention of effects; and to test and refine the battery of outcome assessments. Primary outcome assessment are tests of attention distraction (subtest from a Useful Field of View Test). This pilot will explore a number of secondary outcome measures including EEG and functional imaging biomarkers of change, measures of general cognitive improvement and measures of function including a driving simulator task.

    at UCSD

  • Napping, Sleep, Cognitive Decline and Risk of Alzheimer's Disease

    Sorry, not yet accepting patients

    This study aimed to pilot test a non-pharmacological (behavioral) treatment program targeting improved cognition through improving 24-h sleep-wake cycle in people with mild cognitive impairment (MCI) or mild Alzheimer's disease. A treatment program incorporating bright light therapy and a modified cognitive behavioral therapy for insomnia will be developed to address 24-hour patterns of sleep. We will then pilot test its feasibility and explore its preliminary effects on improving sleep/napping and cognition in patients with MCI or mild Alzheimer's disease.

    at UCSF