Summary

for people ages 18-55 (full criteria)
healthy people welcome
at UC Davis
study started
estimated completion:
Emanual Maverakis (ucdavis)

Description

Summary

This study is designed to identify the cells of the immune system that cause skin disease such as psoriasis and mycosis fungoides. Blood samples from many patients will be compared in hopes of finding common cells and molecules responsible for skin diseases. Results of this study will increase our knowledge about immune mediated skin disease.

Official Title

T Cell Repertoire Analysis of Immune Mediated Skin Diseases

Details

The aim of the study is to characterized the T cell repertoire of individuals with immune mediated skin disease (e.g. psoriasis and mycosis fungoides). Peripheral blood with be collected from volunteers with psoriasis, mycosis fungoides and age matched controls. Fifteen tablespoons of blood will be collected prior to the initiation of treatment and again after the patient shows a clinical response to treatment. The time between blood draws will be no less than 3 months. There will be no more than two blood draws per patient. Blood samples will be used to determine the patient's HLA haplotype via PCR and DNA sequencing. After the patient's haplotype has been established the activated T cell repertoire will be analyzed for clonal expansions. Clonal expansions in the T cell repertoire will be determined by immunoscope analysis, which is a PCR based technique.

Keywords

Psoriasis Mycosis Fungoides Mycoses Skin Diseases

Eligibility

You can join if…

Open to people ages 18-55

  • Have an immune mediated skin disease, such as psoriasis or mycosis fungoides
  • Are not taking immunosuppressive medications, which may interfere with T cell analysis.

You CAN'T join if...

  • are taking immunosuppressive medications, which may interfere with T cell analysis

Location

  • University of California, Davis Department of Dermatology accepting new patients
    Sacramento California 95816 United States

Lead Scientist

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, Davis
Links
University of California-Davis Department of Dermatology Clinical Research
ID
NCT00368784
Study Type
Observational
Last Updated