Summary

Location
at UC Irvine
Dates
study started
estimated completion

Description

Summary

The Swap Out Trial is a cluster randomized controlled trial of HCA hospitals, evaluating the non-inferiority of two decolonization regimens: Arm 1 Routine Care: ICU nasal decolonization with mupirocin twice daily for 5 days in the context of chlorhexidine for daily bathing; Arm 2 Intervention: ICU nasal decolonization with iodophor twice daily for 5 days in the context of chlorhexidine for daily bathing Note: that enrolled "subjects" represents 137 individual HCA Hospitals (representing ~235 ICUs) that have been randomized.

Official Title

Cluster-randomized Non-inferiority Trial Comparing Mupirocin vs Iodophor for Nasal Decolonization of ICU Patients to Assess Impact on S. Aureus Clinical Cultures and All-cause Bloodstream Infection During Routine Chlorhexidine Bathing

Keywords

Staphylococcus Aureus MRSA healthcare-associated infections mupirocin iodophor resistance Arm 1. Routine Care (Mupirocin/CHG) Arm 2. Iodophor/CHG Decolonization

Eligibility

You can join if…

  • Inclusion criteria includes all U.S. HCA hospitals with an adult ICU;
  • Note: Unit of randomization is the hospital, but the participants are hospital adult ICUs
  • All patients within adult ICUs are included, including rare patients <18 years and >=12 years.

You CAN'T join if...

  • Exclusion criteria includes ICUs with an average length of stay of less than 2 days;
  • HCA hospitals that are not able to transfer or merge data into the centralized data warehouse for the baseline and intervention periods of the study are also excluded.

Locations

  • West Hills Hospital & Medical Center
    West Hills California 91307 United States
  • Los Robles Regional Medical Center
    Thousand Oaks California 91360 United States

Details

Status
in progress, not accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Harvard Pilgrim Health Care
ID
NCT03140423
Phase
Phase 4
Study Type
Interventional
Last Updated