Summary

for people ages 18 years and up (full criteria)
healthy people welcome
at UCLA
study started
estimated completion:
Holden H Wu (ucla)

Description

Summary

The objective of this study is to develop and evaluate novel magnetic resonance imaging (MRI) protocols for studying the structure and function of the human body using 1.5Tesla and 3.0Tesla MRI scanners with or without the use of an MRI contrast agent.

Official Title

Free-Breathing Liver Fat and Iron Quantification Using 3D Stack-of-Radial MRI

Details

This study will include on-going technical development work for the non-invasive diagnosis of liver fat or iron accumulation and other abnormalities. MRI is a non-invasive imaging technique with no known side effects. The study will utilize imaging equipment that is used routinely in numerous hospitals and clinics around the world.

The project seeks to address optimization of the imaging methodology at 1.5 Tesla and 3.0 Tesla in the liver and abdomen in order to improve clinical evaluation and care of future patients. Non contrast MRI studies will be performed in normal healthy subjects. In addition, the study will include subjects with confirmed disease or who have suspicion for disease, and are undergoing contrast or non-contrast MR imaging as part of their standard of care. Up to fourty-two (42) male or female subjects eighteen years of age and older will be studied in total (number includes healthy subjects and non-healthy subjects).

Currently, clinical MRI exams are of adequate spatial and temporal resolution, sufficient quantitative accuracy, and acceptable exam duration, but improvements in each of these areas would benefit the care of future patients. For example, improvements in spatial and temporal resolution may confer greater conspicuity of disease and shortening the exam duration can be expected to improve patient acceptance and minimize motion artifacts. The study explores innovative ideas about ways to improve MRI exams to have impact in all three of these areas.

Current MRI techniques for fat and iron quantification in the liver and abdomen are challenged by respiratory and organ motion. As a result, imaging parameters (coverage, resolution, etc) and TE selection for fat/iron quantification are compromised to accommodate a short breath-held 2D or 3D scan, which can still be affected by motion artifacts and even unachievable for patients with limited breath-holding capability. Therefore, the study aims to achieve robust free-breathing fat/iron quantification in the liver and abdomen using innovative MRI techniques and algorithms.

Keywords

Liver Diseases MRI magnetic resonance imaging fat quantification iron quantification Magnetic Resonance Imaging (MRI)

Eligibility

You can join if…

Open to people ages 18 years and up

  1. Healthy Volunteers:
  2. Healthy subjects 18 years or older
  3. Clinical Patients:
  4. Patients who are 18 years or older and who are scheduled for a routine clinically indicated MRI exam at University of California Los Angeles

You CAN'T join if...

  1. Healthy Volunteers:
  2. Age less than 18 years
  3. Subject with the following devices/implants/conditions will be excluded:
  4. cardiac pacemakers
  5. defibrillators
  6. cochlear implants
  7. intraocular metallic foreign bodies
  8. intracranial aneurysm clips
  9. claustrophobia
  10. Subjects will be excluded if they have a history of severe renal disease(Creatinine level >2.5 mg/dl or Glomerular Filtration Rate <15 ml/minute/1.73m2 )or allergy to MRI contrast agents ("dyes"). Healthy volunteers will not be studied with these agents.
  11. Pregnant subjects will not be enrolled. Although there is no data to suggest that MRI is harmful to the fetus, this study is limited to non-pregnant subjects.
  12. Clinical Patients:
  13. Age less than 18 years
  14. Subject with the following devices/implants/conditions will be excluded:
  15. cardiac pacemakers
  16. defibrillators
  17. cochlear implants
  18. intraocular metallic foreign bodies
  19. intracranial aneurysm clips
  20. claustrophobia
  21. Subjects will be excluded if they have a history of severe renal disease(Creatinine level >2.5 mg/dl or Glomerular Filtration Rate <15 ml/minute/1.73m2 )or allergy to MRI contrast agents ("dyes").
  22. Pregnant subjects will not be enrolled. Although there is no data to suggest that MRI is harmful to the fetus, this application is limited to non-pregnant subjects.

Location

  • University of California Los Angeles accepting new patients
    Los Angeles California 90024 United States

Lead Scientist

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, Los Angeles
ID
NCT03162302
Study Type
Observational
Last Updated