Summary

for people ages 18 years and up (full criteria)
at UCLA UCSD
study started
estimated completion:

Description

Summary

This study is a Phase 2, open-label, multicenter study evaluating adoptive cell therapy (ACT) with autologous TIL therapy (LN-145) in combination with Anti-PD-L1 inhibitor durvalumab.

Official Title

A Phase 2 Study to Assess the Efficacy and Safety of Autologous Tumor Infiltrating Lymphocytes (LN-145) In Combination With Anti-PD-L1 Inhibitor Durvalumab (MEDI4736) in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

Details

LN-145 is an adoptive cell transfer therapy that utilizes an autologous TIL manufacturing process, as originally developed by the NCI. The cell transfer therapy used in this study involves patients receiving a nonmyeloablative (NMA) lymphocyte depleting preparative regimen, followed by infusion of autologous TIL followed by the administration of a regimen of IL-2.

Keywords

Non Small Cell Lung Cancer LN-145 Cell Therapy Autologous Adoptive Cell Transfer Cellular Immuno-therapy TIL IL-2 Durvalumab Lung Neoplasms Carcinoma, Non-Small-Cell Lung Antibodies, Monoclonal

Eligibility

You can join if…

Open to people ages 18 years and up

  • Confirmed diagnosis of Stage III or Stage IV NSCLC and progressed after ≤ 3 lines of prior systemic therapy in the locally advanced or metastatic setting
  • Have at least 1 lesion resectable for TIL generation
  • Measurable disease as defined by RECIST v1.1
  • Male or female, ≥ 18 years of age
  • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1, and estimated life expectancy of ≥ 3 months
  • Adequate bone marrow function at screening
  • Adequate organ function at screening
  • A washout period from prior anticancer therapy(ies) of a minimum duration is required prior to first study treatment
  • Recovered from all prior anticancer therapy-related AEs to Grade 1 or less (per CTCAE v4.03) prior to enrollment
  • Female patients of childbearing potential and male patients with partners of childbearing potential patient must agree to use contraception while on study and during the timeframes as specified following the last dose of study drug(s) received,or until the first dose of the subsequent anticancer therapy, whichever is longer
  • Evidence of postmenopausal status or negative urine or serum pregnancy test for female premenopausal patients

You CAN'T join if...

  • History of other malignancies, except for the following: adequately treated nonmelanoma skin cancer, curatively treated in-situ cancer of the cervix,curatively-treated thyroid cancer, or other solid tumors curatively treated with no evidence of disease for ≥ 3 years
  • Patients who have received prior cell therapy
  • Patients who have received prior checkpoint inhibitors: such as anti-PD-1, anti-PD-L1 inhibitors, and durvalumab
  • Active or prior documented autoimmune or inflammatory disorders
  • History of primary or acquired immunodeficiency syndrome, history of allogeneic organ transplant that requires therapeutic immunosuppression
  • Received live or attenuated vaccination within 28 days prior to the start of NMA-LD
  • Patients with a history of hypersensitivity to any component of the study drugs
  • Mean QT interval ≥ 470 msec
  • Patients who have a left ventricular ejection fraction (LVEF) of < 45% or who are New York Heart Association (NYHA) Class 2 or higher
  • Serious illnesses or medical conditions, which would pose increased risk for study participation and/or compliance with the protocol
  • Patients who have obstructive or restrictive pulmonary disease and have a documented FEV1 (forced expiratory volume in 1 second) of ≤ 60%
  • Active central nervous system metastases and/or leptomeningeal disease
  • Female patients who are pregnant or breastfeeding
  • Active infection including tuberculosis (TB), hepatitis B, hepatitis C, or HIV
  • Current or prior use of immunosuppressive medication within 28 days before the first dose of study treatment, with the exceptions of intranasal and inhaled corticosteroids or systemic corticosteroids at physiological doses, which are not to exceed 10 mg/day of prednisone, or an equivalent corticosteroid

Locations

  • University of California San Diego, Morres Cancer Center accepting new patients
    La Jolla California 92093 United States
  • University of California, Los Angeles, Santa Monica Hematology/Oncology accepting new patients
    Los Angeles California 90095 United States

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Iovance Biotherapeutics, Inc.
ID
NCT03419559
Phase
Phase 2
Study Type
Interventional
Last Updated