Sucrose-sweetened Beverage in African-American and Caucasian Women.

Open to females ages 18-45

- BMI 25 - 35 kg/m2

• Does not identify as African-American or non-hispanic White
• Glucose intolerance (fasting glucose >100 mg/dl)
• Evidence of liver disorder (AST or ALT >200% upper limit of normal range)
• Evidence of kidney disorder (>2.0mg/dl creatinine)
• Evidence of thyroid disorder (out of normal range)
• Systolic blood pressure consistently over 140mmHg or diastolic blood pressure over 90mmHg
• Triglycerides > 150mg/dl
• LDL-C > 130mg/dl
• Hemoglobin < 8.5 g/dL
• Pregnant or lactating women
• Current, prior (within 12 months), or anticipated use of any hypolipidemic or anti-diabetic agents PROTOCOL TITLE: The Effects of Sucrose Beverage on

African-American and Caucasian Women (SAAC) Study Page 4 of 18 Revised: November 27, 2013

• Use of thyroid, anti-hypertensive, anti-depressant, weight loss medications or any other medication which, in the opinion of the investigator, may confound study results
• Use of chronic corticosteroids (everyday use for a month or longer)
• Use of tobacco
• Strenuous exerciser (>3.5 hours/week at a level more vigorous than walking)
• Surgery for weight loss
• Diet exclusions: Food allergies, special dietary restrictions, food allergies, routine consumption of less than 3 meals/day, routine ingestion of more than 2 sugar-sweetened beverages or 1 alcoholic beverage/day, unwillingness to consume any food on study menu
• Veins that are assessed by the CCRC R.N.s as being unsuitable for long-term infusions and multiple blood draws from a catheter
• Any other condition that, in the opinion of the investigators, would put the subject at risk
• We will exclude individuals from each of the following special populations:
  • Adults unable to consent
  • Individuals who are not yet adults (infants, children, teenagers < 18 years)
  • Pregnant women
  • Prisoners