Summary

for people ages 8-35 (full criteria)
healthy people welcome
at UC Irvine
study started
estimated completion:

Description

Summary

The goal of this research is to determine whether 10-weeks of exercise training can benefit asthmatic children and young adults with a history of exercise-induced bronchoconstriction (EIB). The investigators will also study an exciting newly discovered aspect of gene expression regulation in the white blood cells known as epigenetics: a process that takes place when genomic changes happen as a result of exposure to the environment. This study is based on emerging exciting new data from this and other laboratories demonstrating that (a) white blood cells play an important role in bronchoconstriction in children, (b) gene and cytokine expression in circulating white blood cells are abnormal in asthma and (c) brief exercise may change genomic and inflammatory- profiles of these cells.Physical activity is an essential component of growth and health in children, thus, this research will lead to improved clinical uses of exercise as preventive and adjunctive therapy in the current epidemic of childhood asthma

Official Title

Exercise Training in Children and Adults: Mechanisms of Allaying Inflammation in Asthma

Keywords

Asthma in Children Asthma Exercise Training

Eligibility

You can join if…

Open to people ages 8-35

  • Good health
  • Physical activity
  • No evidence of disease or disability
  • Diagnosed with persistent asthma (asthma subjects)
  • BMI<95 percentile

You CAN'T join if...

  • Use of illegal drugs or alcohol
  • Very high physical fitness
  • Pregnancy
  • More than two asthma attack per week (asthma subjects)

Location

  • Pediatric Exercise and Genomics Research Center, University of California, Irvine accepting new patients
    Irvine California 92697/92617 United States

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Shlomit Aizik
ID
NCT03716219
Study Type
Interventional
Last Updated