for people ages 18-80 (full criteria)
study started
estimated completion



Overactive bladder (OAB) affects 12-30% of the world's population. The accompanying urinary urgency, urinary frequency and incontinence can impair the ability to work, interact in social activities and can result in poor social functioning. Multiple treatment modalities are available for overactive bladder. However, each therapy has drawbacks that limit its application in certain patient populations. For example, oral medications have significant side effects and suffer from poor adherence. Botulinum toxin injection into the bladder wall is invasive, requires re-treatment on a regular basis and carries a risk of urinary retention. Current neuromodulatory techniques are invasive and require highly-specialized care. Therefore, a need exists for a non-invasive, well-tolerated and easily administered therapy for OAB. Transcutaneous spinal cord stimulation (TSCS) has been developed and tested in able bodied individuals to initiate locomotor function as well as in the SCI population for lower extremity and upper extremity function. More recently, we have tested this SCI patients to enable lower urinary tract function and decrease detrusor overactivity, resulting in improved continence.

Official Title

Evaluation of Noninvasive Spinal Cord Stimulation for Neurogenic and Idiopathic Overactive Bladder


Overactive Bladder Incontinence, Urge Neurogenic Bladder Urinary Bladder, Neurogenic Urinary Bladder, Overactive Urinary Incontinence, Urge Noninvasive spinal cord stimulation Actual stimulation


You can join if…

Open to people ages 18-80

  1. Age between 18 and 80 years
  2. Known diagnosis of overactive bladder, confirmed by:
  3. presence of urinary frequency, urgency
  4. frequent small-volume voids on frequency-volume chart
  5. high score on ICIQ-OAB, ICIQ-OABQOL, and OAB-q questionnaires

You CAN'T join if...

  1. Younger than 18 years of age
  2. Older than 80 years of age
  3. Presence of lower urinary tract symptoms suggestive of urinary retention or obstruction
  4. Finding of an elevated post-void residual (>100 ml) on an ultrasonographic bladder scan
  5. History of spinal cord injury, spina bifida or other neurological disease affecting the spinal cord
  6. Acute or current urinary tract infection
  7. History of neuromodulation for overactive bladder (sacral nerve stimulation or peripheral tibial nerve stimulation)
  8. Current or planned pregnancy


  • University of Southern California accepting new patients
    Los Angeles California 90033 United States


accepting new patients
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University of Southern California
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