EXPLORER PET/CT in Healthy Volunteers

Open to people ages 18 years and up

• Men and women, 18 years of age or older
• Willing and able to fast for at least 6 hours before and for the duration of the scan
• Willing and able to lay motionless in a supine position for 60 and 20 minutes at separate timepoints.
• Willing and able to give informed consent

• No Primary Care Physician
• Body weight >240 kg
• Allergy to iodine contrast (only for subjects enrolled in Arm 3)
• Creatinine levels > 1.5 mg/dL or estimated glomerular filtration rate (eGFR) < 60 ml/minute (only for subjects enrolled in Arm 3)
• Recent (1 month) contrast enhanced CT
• Any known concomitant acute infection (including upper respiratory infection, genitourinary infections, etc.
• History of metastatic or newly (last 5 years) diagnosed locally invasive cancer.
• Chemotherapy in the last 5 years
• Radiation therapy in the last 3 years
• Major surgery within the last 6 months.
• Pregnancy or breast-feeding
• Diabetes
• Fasting blood glucose level > 160 mg/dL before administration of FDG
• Prisoners
• The standard MRI contraindications apply, including but not limited to:

Having a pacemaker or other implanted electronic device. Metal foreign bodies, aneurysm clips, heart valve prosthesis, vascular stents, cochlear implants, embolization coils, gunshot wounds with retained bullet fragments, penile implant, IUCD.

Claustrophobia