Summary

for people ages 18 years and up (full criteria)
at UC Irvine UCSF
study started
estimated completion
Sai-Hong Ignatius Ou(uci)Pamela Munster(ucsf)

Description

Summary

The reason for this study is to see if the study drug LY3499446 is safe and effective in participants with solid tumors with KRAS G12C mutation.

Official Title

A Phase 1/2 Study of LY3499446 Administered to Patients With Advanced Solid Tumors With KRAS G12C Mutation

Keywords

Advanced Solid Tumor Non-Small Cell Lung Cancer Colorectal Cancer Carcinoma, Non-Small-Cell Lung Colorectal Neoplasms Docetaxel Cetuximab Erlotinib Hydrochloride Abemaciclib Erlotinib

Eligibility

You can join if…

Open to people ages 18 years and up

  • Participants must have diagnosis of a solid tumor with KRAS G12C mutation that did not respond to at least 1 line of standard therapy and has spread to other part(s) of the body
  • For phase II, participants must be willing to have new tumor tissue biopsies (doctor removes a small amount of tissue) during the study if it does not cause undue risks to health
  • Participants must be willing to use highly effective birth control
  • Participants must have adequate organ function
  • Participants must be able to swallow capsules

You CAN'T join if...

  • Participants must not have certain infections such as hepatitis or tuberculosis or HIV that is not well controlled
  • Participants must not have another serious medical condition including a serious heart condition, such as congestive heart failure, unstable angina pectoris, or heart attack within the last three months
  • Participants must not have cancer of the central nervous system that is not stable
  • Participants must not be pregnant or breastfeeding
  • Participants must not use herbal supplements

Locations

  • Univ of California Irvine College of Medicine not yet accepting patients
    Orange California 92868 United States
  • University of California, San Francisco not yet accepting patients
    San Francisco California 94158 United States

Lead Scientists

  • Sai-Hong Ignatius Ou (uci)
    Health Sciences Professor, Medicine. Authored (or co-authored) 5 research publications
  • Pamela Munster (ucsf)
    Professor, Medicine. Authored (or co-authored) 120 research publications

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Eli Lilly and Company
Links
A Study of LY3499446 in Participants With Advanced Solid Tumors With KRAS G12C Mutation
ID
NCT04165031
Phase
Phase 1/2
Study Type
Interventional
Last Updated