Convalescent Plasma to Stem Coronavirus (CSSC-001)

Open to people ages 18 years and up

1. Subjects must be 18 years of age or older.
2. Close contact* exposure to person with COVID-19 within 96 hours of enrollment (and 120 hours of receipt of plasma) defined as:

2.1 Living in the same household as, being an intimate partner of, or providing care in a non-healthcare setting (such as a home) for a person with symptomatic laboratory-confirmed COVID-19 infection without using recommended precautions for home care and home isolation.

2.2 HCP who have had prolonged close contact with patients with COVID-19 who were not wearing a face mask while HCP nose and mouth were exposed to material potentially infectious with the virus causing COVID-19.

2.3 Being present in the room for procedures that generate aerosols or during which respiratory secretions are likely to be poorly controlled (e.g., cardiopulmonary resuscitation, intubation, extubation, bronchoscopy, nebulizer therapy, sputum induction) on patients with COVID-19 when the healthcare providers' eyes, nose, or mouth were not protected.

1. Receipt of any blood product in past 120 days.
2. Medical, psychiatric,cognitive illness or recreational drug/alcohol use that in the opinion of the principal investigator, would affect subject safety and/or compliance.
3. Symptoms consistent with COVID-19 infection (fevers, acute onset cough, shortness of breath) at time of screening.
4. Laboratory evidence of COVID-19 infection at time of screening.
5. History or known laboratory evidence of previous COVID-19 infection.
6. History of prior reactions to transfusion blood products.
7. inability to complete therapy with the study product within 24 hours after enrollment.