Feasibility of Gamma Transcranial Alternating Current Stimulation to Reduce Beta-amyloid Load and Improve Memory

a study on Mild Cognitive Impairment

Summary

Eligibility
for people ages 55-75 (full criteria)
Healthy Volunteers
healthy people welcome
Location
at UCSF
Dates
study started
estimated completion
Principal Investigator
by Theodore Zanto, Ph.D. (ucsf)
Photo of Theodore Zanto
Theodore Zanto

Description

Summary

This project will assess the feasibility of transcranial alternating current stimulation in the gamma band to lower beta-amyloid load and improve memory performance.

Keywords

Mild Cognitive Impairment Cognitive Dysfunction Transcranial alternating current stimulation

Eligibility

You can join if…

Open to people ages 55-75

  • English speaking
  • Grade 12 or more education
  • Normal or corrected to normal vision and hearing
  • Ability to complete cognitive tasks
  • Ability to cooperate and comply with all study procedures
  • Ability to tolerate tACS
  • Self-reported memory complaint
  • Diagnosed with mild cognitive impairment
  • Amyloid positive

You CAN'T join if...

  • Neurological or psychiatric disorders other than mild cognitive impairment
  • Receiving investigational medications or have participated in a trial with investigational medications within last 30 days
  • Family history of epilepsy
  • Implanted electronic devices (e.g., pacemaker)
  • Prior head trauma
  • Pregnant
  • IQ < 80
  • Taking cholinesterase inhibitory, memantine, or psychotropic medication
  • Taking anti-depressants or anti-anxiety medication
  • Color blind
  • Substance abuse
  • Glaucoma
  • Macular degeneration
  • Amblyopia (lazy eye)
  • Strabismus (crossed eyes)

Location

  • University of California, San Francisco accepting new patients
    San Francisco California 94158 United States

Lead Scientist at UC Health

  • Theodore Zanto, Ph.D. (ucsf)
    Ted's research revolves around 1) the characterization of neural networks and mechanisms underlying cognitive control, 2) understanding how these systems change with age and 3) exploring cognitive training and non-invasive brain stimulation approaches to remediate cognitive control declines.

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
ID
NCT04646499
Study Type
Interventional
Last Updated