Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at UCLA
Dates
study started
estimated completion
Principal Investigator
by Kelly Rentscher, PhD (ucla)

Description

Summary

This project aims to elucidate the important protective elements of social relationships and identify concrete, modifiable behavioral factors that contribute to biological and phenotypic aging in hematopoietic cell transplantation (HCT) survivors and can be used to develop biologically informed interventions to improve quality of life and prolong the healthspan of individuals with accelerated aging.

Official Title

Accelerated Biological and Phenotypic Aging in Hematopoietic Cell Transplant Survivors: Social Support as a Protective Factor

Details

PRIMARY OBJECTIVES: I. Examine associations between social support, strain, and isolation and phenotypic aging over the 1-year recovery period. II. Examine associations between social support, strain, and isolation and biological aging over the 1-year recovery period. III. Test biological aging as a mediator linking social processes and phenotypic aging. EXPLORATORY OBJECTIVE: I. Test sex differences in Aims 1 and 2. OUTLINE: Adopting a prospective design, participants will complete comprehensive assessments of social processes at 100 days and 1 year after HCT that combine reports of social support, strain, and isolation with a naturalistic observation tool, the Electronically Activated Recorder (EAR), which captures ambient sound bites to assess social interactions in survivors' daily lives16. At each time point, participants will also provide reports of symptoms to characterize phenotypic aging, including cognitive, physical, and functional complaints, and blood samples to assess biological aging, including cellular senescence, DNA damage, SASP, and cellular stress using genome-wide RNA sequencing. Relevant clinical information that could influence biological aging will also be collected from patients' medical records to consider as covariates.

Keywords

Hematopoietic and Lymphoid Cell Neoplasm Hematologic Neoplasms Biospecimen Collection Electronic Health Record Review

Eligibility

You can join if…

Open to people ages 18 years and up

  • Aged 18 years and older who are competent to give their informed consent
  • Ability to read, speak, and understand English
  • Received a hematopoietic cell transplant at the University of California, Los Angeles Hematologic Malignancy/Stem Cell Transplantation Program clinic within the previous 100 days

You CAN'T join if...

  • Less then Aged 18 years and older who are competent to give their informed consent
  • Cannot read, speak, and understand English
  • Has not received a hematopoietic cell transplant at the University of California, Los Angeles Hematologic Malignancy/Stem Cell Transplantation Program clinic within the previous 100 days

Location

  • University of California at Los Angeles accepting new patients
    Los Angeles California 90095 United States

Lead Scientist at University of California Health

  • Kelly Rentscher, PhD (ucla)
    Assistant Adjunct Professor, Psychiatry and Biobehavioral Sciences. Authored (or co-authored) 19 research publications.

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Jonsson Comprehensive Cancer Center
ID
NCT04892823
Study Type
Observational
Last Updated