Effects of Japanese Red Wines on Vascular Function in Adult Men

Open to males ages 50-70

• Male: 50-70 years old
• Subject is willing and able to comply with the study protocols.
• Subject is willing to participate in all study procedures
• BMI 18.5 - 40 kg/m2
• Weight ≥ 110 pounds
• Prescription medication if on a 6-month self-reported stable dose
• Regularly consume alcoholic beverages (2 drinks/week to 2 drinks/day)
• Non-smokers

• One standard drink of alcoholic beverages is defined as follow:

  12-ounces of beer (5% alcohol content) (~1 regular bottle). 8-ounces of malt liquor (7% alcohol content) (~1 regular bottle). 5-ounces of wine (12% alcohol content) (~½ glass) 1.5-ounces of 80-proof (40% alcohol content) distilled spirits or liquor (e.g., gin, rum, vodka, whiskey) (~ 1 shot)

• BMI ≥ 40 kg/m2
• Daily use of aspirin or NSAIDs
• Dislike or allergic to any food, especially wine, grape, and alcohol
• Vegan, Vegetarians, food faddists, or those consuming a non-traditional diet
• Alcohol consumption < 2 drinks/week (i.e. 1 bottle of beer, ½ glass of wine, and 1 shot of hard liquor)
• Alcohol consumption > 2 drinks/ day
• Fruit consumption ≥ 2 cups/day
• Vegetable consumption ≥ 3 cups/day
• Fatty Fish ≥ 3 times/week
• Coffee/tea ≥ 3 cups/day
• Dark chocolate ≥ 3 oz/day
• Self-reported restriction of physical activity due to a chronic health condition
• Self-reported chronic/routine high intensity exercise
• Self-reported diabetes
• Blood pressure ≥ 140/90 mm Hg
• Self-reported renal or liver disease
• Self-reported heart disease, which includes cardiovascular events and Stroke
• Self-reported Cushing's syndrome
• Self-reported chronic/routine high-intensity exercise
• Inability to properly place or wear the PAT probes or abnormal measurements on pre-screening PAT
• Abnormal Liver or Chemistry panels (laboratory values outside the reference range) if determined to be clinically significant by the study physician.
• Self-reported cancer within the past 5 years
• Self-reported malabsorption
• Use of multi-vitamin and minerals other than a general formula of vitamins and minerals that meet the recommended dietary allowance (RDA)
• Not willing to stop any supplement use, including herbal, plant or botanical, fish oil, oil supplements a month prior to study enrollment.
• Indications of substance or alcohol abuse within the last 3 years
• Current enrollee in a clinical research study.
• Reactive hyperemia index (RHI) value ≥ 2.8 (measured by PAT at the first study visit)
• Raynaud's disease, history of bleeding disorder and/or abnormal bleeding, and history of gastrointestinal ulceration and/or bleeding
• Under current medical supervision
• 1 ug/ml and 3 ug/ml collagen screening maximal platelet aggregatory response of < 65%.
• Platelet number or mean platelet values that are outside of the normal reference range as indicated on a complete blood cell count report from the University of California Davis Medical Center

• Current diagnosis of anemia; or a screening hemoglobin and hematocrit that is less than the normal reference range.Individuals with blood clotting or platelet defect disorders

  The following special populations will be excluded:

• Individuals who are not yet adults (infants, children, teenagers)
• Pregnant women
• Prisoners