Join Our Study for Men - Japanese Red Wines and Heart Health!

Men between ages 50 and 70 can help researchers test the effect of different Japanese red wines on cardiovascular health

Open to males ages 50-70

• Male: 50-70 years old
• Subject is willing and able to comply with the study protocols.
• Subject is willing to participate in all study procedures
• BMI 18.5 - 40 kg/m2
• Weight ≥ 110 pounds
• Prescription medication if on a 6-month self-reported stable dose
• Regularly consume alcoholic beverages (2 drinks/week to 2 drinks/day)
• Non-smokers
• One standard drink of alcoholic beverages is defined as follow:

12-ounces of beer (5% alcohol content) (~1 regular bottle). 8-ounces of malt liquor (7% alcohol content) (~1 regular bottle). 5-ounces of wine (12% alcohol content) (~½ glass) 1.5-ounces of 80-proof (40% alcohol content) distilled spirits or liquor (e.g., gin, rum, vodka, whiskey) (~ 1 shot)

• BMI ≥ 40 kg/m2
• Daily use of aspirin or NSAIDs
• Dislike or allergic to any food, especially wine, grape, and alcohol
• Vegan, Vegetarians, food faddists, or those consuming a non-traditional diet
• Alcohol consumption < 2 drinks/week (i.e. 1 bottle of beer, ½ glass of wine, and 1 shot of hard liquor)
• Alcohol consumption > 2 drinks/ day
• Fruit consumption ≥ 2 cups/day
• Vegetable consumption ≥ 3 cups/day
• Fatty Fish ≥ 3 times/week
• Coffee/tea ≥ 3 cups/day
• Dark chocolate ≥ 3 oz/day
• Self-reported restriction of physical activity due to a chronic health condition
• Self-reported chronic/routine high intensity exercise
• Self-reported diabetes
• Blood pressure ≥ 140/90 mm Hg
• Self-reported renal or liver disease
• Self-reported heart disease, which includes cardiovascular events and Stroke
• Self-reported Cushing's syndrome
• Self-reported chronic/routine high-intensity exercise
• Inability to properly place or wear the PAT probes or abnormal measurements on pre-screening PAT
• Abnormal Liver or Chemistry panels (laboratory values outside the reference range) if determined to be clinically significant by the study physician.
• Self-reported cancer within the past 5 years
• Self-reported malabsorption
• Use of multi-vitamin and minerals other than a general formula of vitamins and minerals that meet the recommended dietary allowance (RDA)
• Not willing to stop any supplement use, including herbal, plant or botanical, fish oil, oil supplements a month prior to study enrollment.
• Indications of substance or alcohol abuse within the last 3 years
• Current enrollee in a clinical research study.
• Reactive hyperemia index (RHI) value ≥ 2.8 (measured by PAT at the first study visit)
• Raynaud's disease, history of bleeding disorder and/or abnormal bleeding, and history of gastrointestinal ulceration and/or bleeding
• Under current medical supervision
• 1 ug/ml and 3 ug/ml collagen screening maximal platelet aggregatory response of < 65%.
• Platelet number or mean platelet values that are outside of the normal reference range as indicated on a complete blood cell count report from the University of California Davis Medical Center
• Current diagnosis of anemia; or a screening hemoglobin and hematocrit that is less than the normal reference range.Individuals with blood clotting or platelet defect disorders

The following special populations will be excluded:

• Individuals who are not yet adults (infants, children, teenagers)
• Pregnant women
• Prisoners