Summary

Eligibility
for people ages 0-17 (full criteria)
Location
at UCLA
Dates
study started
estimated completion

Description

Summary

This study will evaluate the pharmacokinetics (PK), pharmacodynamics (PD), safety, and tolerability of AZD7442 administered intramuscularly (IM) or intravenously (IV) in pediatric participants aged ≥ 29 weeks GA to < 18 years.

Official Title

Open-Label, Uncontrolled, Single Dose Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of AZD7442 in Pediatric Participants Aged ≥ 29 Weeks Gestational Age to < 18 Years

Details

This is a Phase I, open-label, uncontrolled, multi-country, multi-center, single-dose study. Initially, 2 cohorts of participants will be enrolled: 1) participants who are severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) negative at screening and have not knowingly been exposed to a SARS-CoV-2 positive individual (pre-exposure prophylaxis); and 2) participants who are SARS-CoV-2 RT-PCR positive at screening and have mild to moderate COVID-19 symptoms. A third cohort might be added for the treatment of severe COVID-19. If included, this third cohort will include participants who are SARS-CoV-2 positive at screening and have severe COVID-19.

Keywords

SARS-CoV-2 AZD7442 Monoclonal antibodies (mAb) COVID-19 EVUSHELD

Eligibility

You can join if…

Open to people ages 0-17

  • Participant must be aged ≥ 29 weeks gestational age (GA) to < 18 years of age.
  • Participant must weigh a minimum of 1.5 kg.

COHORT 1

  • Increased risk of severe COVID-19 because of immunocompromised state or one or more comorbid conditions that increase the risk of severe COVID-19.
  • Increased risk for SARS-CoV-2 infection.
  • Medically stable (disease not requiring significant change in therapy or hospitalization for worsening disease during the one month prior to enrollment).
  • A negative RT-PCR test collected ≤ 3 days prior to Day 1 or a negative rapid SARS-CoV-2 antigen test at screening.
  • No COVID-19 symptoms prior to enrollment within 10 days of dosing.
  • Increased risk for SARS-CoV-2 infection.

COHORT 2

  • Increased risk of severe COVID-19 because of immunocompromised state or one or more comorbid conditions that increase the risk of severe COVID-19.
  • Medically stable (disease not requiring significant change in therapy or hospitalization for worsening disease during the one month prior to enrollment).
  • A positive RT-PCR test collected ≤ 3 days prior to Day 1 or a positive rapid SARS-CoV-2 antigen test at screening.
  • Symptomatic participants must be dosed with IMP no more than 7 days from the self-reported date of first reported sign/symptom.
  • Oxygenation saturation of ≥ 92% obtained at rest within 24 hours prior to Day 1 unless the potential participant regularly receives chronic supplementary oxygen for an underlying lung condition.

COHORT 3

  • Participants hospitalized with COVID-19 with a time between onset of symptoms and dosing AZD7442 of ≤ 7 days.
  • A positive RT-PCR test collected ≤ 3 days before Day 1 or a positive rapid SARS-CoV-2 antigen test at screening.
  • Spontaneous blood Alanine Aminotransferase (ALT)/Aspartate Transaminase (AST) levels ≤ 5 times the ULN.
  • Glomerular Filtration Rate (GFR) ≥ 30 mL/min.

Participants will receive IM AZD7442 unless they meet any of the following criteria for IV administration:

  • Severe COVID-19.
  • Contraindication of intramuscular (IM) dose due to thrombocytopenia, coagulation defects or any other condition that would compromise the absorption of AZD7442 or safety of the participant.
  • A central IV line. - Physician considers IV the appropriate route.

You CAN'T join if...

All Cohorts

  • Cohort 1: Significant infection or other acute illnesses including fever on or the day prior to receiving AZD7442.
  • History of SARS-CoV-1 or Middle East Respiratory Syndrome Coronavirus (MERS-CoV).
  • Cohorts 1 and 2: Current need for immediate medical attention or current need for hospitalization.
  • Mechanical ventilation or extracorporeal membrane oxygenation requirement for COVID-19.
  • History of allergic or reaction to any component of the study drug formulation.
  • History of hypersensitivity, injection/infusion-relation reactions or severe adverse reactions following administration of a monoclonal antibody (mAb).
  • Co-morbidity requiring surgery within 7 days prior to study entry or is deemed life-threatening within 30 days prior to study entry.
  • Prior receipt of convalescent COVID-19 plasma/sera or hyperimmune globulin therapy.
  • Prior receipt of mAb/biologic indicated for the prevention of SARS-CoV-2, treatment of COVID-19, or expected receipt during the period of study follow-up.
  • Prior receipt of a COVID-19 vaccine < 60 days before screening.
  • Post-pubertal females who are pregnant or breast-feeding.
  • History of alcohol or drug abuse or positive urine drug or alcohol screening within the past 2 years.

Locations

  • Research Site not yet accepting patients
    Los Angeles California 90095 United States
  • Research Site accepting new patients
    Long Beach California 90806 United States
  • Research Site not yet accepting patients
    Stanford California 94305 United States

Details

Status
accepting new patients at some sites,
but this study is not currently recruiting here
Start Date
Completion Date
(estimated)
Sponsor
AstraZeneca
ID
NCT05281601
Phase
Phase 1 COVID-19 Research Study
Study Type
Interventional
Participants
Expecting 100 study participants
Last Updated