ALK Gene Translocation clinical trials at UC Health
2 in progress, 2 open to new patients
Pediatric MATCH: Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With ALK or ROS1 Genomic Alterations
open to eligible people ages 12 months to 21 years
This phase II trial studies how well ensartinib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with ALK or ROS1 genomic alterations that have come back or do not respond to treatment and have spread to other places in the body. Ensartinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Targeted Chemotherapy, Crizotinib, or Placebo in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer after surgery
“Can targeted chemotherapy, Crizotinib, stop the growth of tumor cells by blocking the a protein from working?”
open to eligible people ages 18 years and up
This randomized phase III trial studies how well crizotinib works in treating patients with stage IB-IIIA non-small cell lung cancer that has been removed by surgery and has a mutation in a protein called anaplastic lymphoma kinase (ALK). Mutations, or changes, in ALK can make it very active and important for tumor cell growth and progression. Crizotinib may stop the growth of tumor cells by blocking the ALK protein from working. Crizotinib may be an effective treatment for patients with non-small cell lung cancer and an ALK fusion mutation.
at UCSDUC Davis