Clinical Trials Open to Healthy Volunteers

• 4-Repeat Tauopathy Neuroimaging Initiative - Cycle 2

  • study on Corticobasal Degeneration and Corticobasal Syndrome
  • open to healthy people ages 40-80

• A Couples-based Intervention for Transgender Women and Their Partners

  • study on HIV/AIDS
  • open to healthy people ages 18 years and up

• A Group-Based Therapeutic Yoga Intervention for Urinary Incontinence in Ambulatory Older Women

  • study on Stress Incontinence and Urinary Incontinence
  • open to healthy females ages 45 years and up

• A Multidimensional Behavioral Intervention for Those at Risk for Alzheimer's Dementia

  • study on Functional Aging and Subjective Cognitive Concerns
  • open to healthy people ages 65 years and up

• A Phase I Study of Lintuzumab-Ac225 in Patients With Refractory Multiple Myeloma

  • study on Multiple Myeloma
  • open to healthy people ages 18 years and up

• A Prospective Trial of Behavioral Therapy for Chronic Cough

  • study on Cough
  • open to healthy people ages 18-90

• A Smartphone App to Improve Physical Activity

  • study on Sedentary Lifestyle
  • open to healthy people ages 65-84

• A study following patients with Huntington's Disease over time

  “Help us learn more about Huntington's Disease”

  • study on Huntington's Disease
  • open to healthy people ages 18 years and up

• A Study of Brain Aging in Vietnam War Veterans

  • study on Brain Injuries and Traumatic Brain Injury
  • open to healthy people ages 50-90

• A Study of Museum-Based Experiences to Reduce Social Isolation and Pain

  “Can participating in museum programs help individuals with chronic pain feel more socially connected? Help us find out!”

  • study on Pain
  • open to healthy people ages 18 years and up

• A Study of Outpatient Cervical Preparation to Reduce Induction Duration in Pregnant Women

  • study on Cervical Ripening and Outpatient
  • open to healthy females ages 18 years and up

• A Study of Psilocybin for Major Depressive Disorder (MDD)

  • study on Depression
  • open to healthy people ages 21-65

• A Study of Satisfaction With School-Based Telemedicine

  “This is a research study to determine parent/guardian satisfaction with care.”

  • study on Physical and Rehabilitation Medicine and Physical Therapy Modalities
  • open to healthy people ages up to 21 years

• A Study of Skin Diseases Brought About by Irregular Immune System Response

  “Help researchers learn more about immune cells that contribute to skin disease”

  • study on Psoriasis and Mycosis Fungoides
  • open to healthy people ages 18-55

• A Study of Stratification and Algorithm in Opioid Use in Shoulder Arthroplasty Patients

  • study on Opioid Use
  • open to healthy people ages 18 years and up

• A Study of Telehealth Intervention for Caregivers of Infants With Early Signs of Autism Spectrum Disorder

  “We hope to learn how to support families concerned with their infants’ development.”

  • study on Autism and Developmental Delay
  • open to healthy people ages 5 months to 12 months

• A Study of the Effect of Mango Intake (Mangifera Indica L.) on Blood Pressure and Blood Glucose in Post-Menopausal Women

  • study on Blood Pressure
  • open to healthy females ages 50-70

• A Study of the Effect of Orange Juice or Sugar-Sweetened Beverages on Risk Factors for Type 2 Diabetes and Cardiovascular Disease

  “In this study, the study team will provide meals and either sugar-sweetened beverages or orange juice.”

  • study on Cardiovascular Risk Factor and Diabetes
  • open to healthy people ages 18-50

• A Study of the Effects of Brain Stimulation on Higher-Order Cognition

  • study on Schizophrenia
  • open to healthy people ages 18-35

• A Study of the Effects of Intermittent Fasting on Energy, Hormones, Body Composition, and Performance in Male Runners

  “The study team hopes to learn more about how time restricted eating affects performance and health in male runners.”

  • study on Fasting and Intermittent Fasting
  • open to healthy males ages 20-40

• A Study of the Experimental Medicine Roflumilast for Severe Asthma

  • study on Asthma
  • open to healthy people ages 18 years and up

• A Study of the Experimental Medicine Ropivacaine for Pain Control After Kidney Transplant

  • study on Postoperative Pain and Kidney Transplant
  • open to healthy people ages 18 years and up

• A Study of Virological Suppression (controlling a viral infection) for HIV-Positive Patients

  “The purpose of this study is to better understand what the best treatment method is to help HIV patients become undetectable.”

  • study on HIV/AIDS
  • open to healthy people ages 18 years and up

• Acceptance and Commitment Therapy for Aging People Living With HIV in Chronic Pain

  • study on HIV/AIDS and Pain
  • open to healthy people ages 50 years and up

• Acoustic and Electrical Stimulation for the Treatment of Tinnitus

  • study on Tinnitus
  • open to healthy people ages 18 years and up

• Acute Assessment of Platelet Reactivity After the Intake of Oleocanthal

  • study on Platelet Aggregation and Metabolic Disease
  • open to healthy males ages 20-45

• Addressing Heavy Alcohol Use Consumption With Kudzu

  • study on Alcohol Use and Sexually Transmitted Infections
  • open to healthy people ages 18-70

• Addressing Obesity in Early Care and Education Settings

  • study on Obesity
  • open to healthy people ages 30 months and up

• Adolescent Master Protocol for Participants 18 Years of Age and Older (AMP Up)

  • study on HIV/AIDS
  • open to healthy people ages 18 years and up

• Adult Study Oxytocin - Behavioral

  • study on Schizophrenia and Oxytocin
  • open to healthy males ages 18-45

• Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)

  • study on Frontotemporal Lobar Degeneration and Progressive Supranuclear Palsy
  • open to healthy people ages 18-85

• Advancing Understanding of Transportation Options

  • study on Diabetic Retinopathy and Macular Degeneration
  • open to healthy people ages 18 years and up

• Alternation in the Human Microbiome With Commonly Used Topical Medications

  • open to healthy people ages 18 years and up

• Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3) Protocol

  • study on Mild Cognitive Impairment and Alzheimer's Disease
  • open to healthy people ages 55-90

• An Examination of Infants' Microbiome, Nutrition, and Development Study.

  “Help us learn about the relationship between infant nutrition, gut health, and development!”

  • study on Microbial Colonization and Child Development
  • open to healthy females ages 21-45

• Androgen Excess as a Cause for Adipogenic Dysfunction in PCOS Women

  • study on Polycystic Ovary Syndrome
  • open to healthy females ages 18-35

• Antigen Presentation and Lymphocyte Response in Parkinson's Disease

  • study on Parkinson's Disease
  • open to healthy people ages 50-90

• Anxiety and Reward Interaction and Prediction of Outcomes in Anorexia Nervosa

  • study on Anorexia and Anxiety Disorders
  • open to healthy females ages 12-19

• Apremilast Pregnancy Exposure Registry

  • study on Arthritis and Psoriasis
  • open to healthy females

• Arbitration Between Habitual and Goal-directed Behavior in Obsessive-compulsive Disorder: Circuit Dynamics and Effects of Noninvasive Neurostimulation

  • study on Obsessive-Compulsive Disorder and Decision-Making
  • open to healthy people ages 18-65

• Arterial Inflammation and E-Cigarettes

  • study on Arterial Inflammation
  • open to healthy people ages 21-45

• Assessment and Prevention of Pain During Ovarian Stimulation in Patients With Endometriosis

  • study on Endometriosis and Ovarian Hyperstimulation
  • open to healthy females ages 18-42

• At-home Transcranial Alternating Current Stimulation During Multitasking

  • study on Multitasking Behavior
  • open to healthy people ages 18-35

• Attachment and Biobehavioral Catch-up for Depression

  • study on Depression and Anxiety Symptoms
  • open to healthy females ages 18-50

• Attitudes and Decision-making After Pregnancy Testing Study

  • study on Unintended Pregnancy and Undesired Pregnancy
  • open to healthy females ages 15-34

• Autonomic Mechanisms of Sleep-dependent Memory Consolidation

  • study on Memory and Sleep
  • open to healthy people ages 18-64

• Benralizumab Pregnancy Exposure Study

  • study on Asthma
  • open to healthy females

• Brain Function in Adolescent Eating Disorders and Healthy Peers

  • study on Eating Disorder
  • open to healthy females ages 14-17

• Brain Health Registry

  • study on Neurodegenerative Disease
  • open to healthy people ages 18 years and up

• BRCA Founder OutReach (BFOR) Study

  • study on BRCA 1 Gene Mutation and BRCA 2 Gene Mutation
  • open to healthy people ages 25 years and up

• CCTG 603: Randomized Controlled Trial of iTAB Plus Motivational Interviewing for PrEP Adherence in Transgender Individuals (The iM-PrEPT Study)

  • study on Patient Adherence and HIV/AIDS
  • open to healthy people ages 18 years and up

• Cellular Aging and Neurobiology of Depression Study

  • study on Depression
  • open to healthy people ages 21-60

• Central Obesity and Cancer Prevention for Chinese American Women

  • study on Obesity and Cancer Prevention
  • open to healthy females ages 18 years and up

• Cervical Preparation With Mifepristone Prior to Osmotic Dilators

  • study on Abortion
  • open to healthy females ages 18-45

• CF And Effects of Drugs Mixed Ex Vivo With Sputum for Mucolytic Treatment

  • study on Cystic Fibrosis and Fibrosis
  • open to healthy people ages 18-65

• Characterization of Adult Subjects for Asthmatic Research Studies

  • study on Asthma
  • open to healthy people ages 18 years and up

• Characterization of Inclusion Body Myopathy Associated With Paget's Disease of Bone and Frontotemporal Dementia (IBMPFD)

  • study on Dementia and Myopathy
  • open to healthy people ages 18 years and up

• Characterization of the Melanoma-Specific Immune Response

  • study on Melanoma and Skin Cancer/Melanoma
  • open to healthy people ages 18-85

• Characterizing Asthma Sputum Elasticity in the UCSF Severe Asthma Research Program

  • study on Asthma
  • open to healthy people ages 18-65

• Childhood Cancer Survivor Study

  • study on Cancer, General
  • open to healthy people

• Clinic-Based Financial Coaching and Family Health and Development

  • study on Economic Problems and Child Development
  • open to healthy people ages 18 years and up

• Clinical and Genetic Evaluation of Individuals With Undiagnosed Disorders Through the Undiagnosed Diseases Network

  • study on Genetic Diseases
  • open to healthy people ages up to 100 years

• Clinical and Molecular Studies in Families With Inherited Eye Disease

  • study on Inherited Eye Disease
  • open to healthy people ages 4 years and up

• Clinical Trial of Anti-oxidant Astaxanthin in Insulin-resistant Subjects

  • study on Metabolic Syndrome
  • open to healthy people ages 18-75

• Coffee and Real-time Atrial and Ventricular Ectopy

  • study on Premature Ventricular Contractions
  • open to healthy people ages 18 years and up

• Cognitive Rehab and Exposure Treatment for Hoarding

  • study on Hoarding Disorder
  • open to healthy people ages 18-85

• Collection of Blood for Multiple Collaborative Studies

  • study on HIV/AIDS
  • open to healthy people ages 18 years and up

• Combined Focused Ultrasound and Calcium Hydroxylapatitie Filler for Skin Laxity and Volume Restoration

  • study on Skin Laxity
  • open to healthy people ages 18-85

• Comparative Effectiveness of MRgFUS Versus CTgRFA for Osteoid Osteomas

  • study on Osteoid Osteoma
  • open to healthy people ages 10 years and up

• Comparing Intra-vaginal Culture of Embryos to In-vitro Culture of Embryos With Minimal Stimulation

  • study on Infertility
  • open to healthy females ages 18-37

• Comparing Preoperative Injection of Mitomycin-C vs. Intraoperative Injection of Mitomycin-C vs. Topical Application of Mitomycin-C (Conventional Use) in Trabeculectomy

  • study on Glaucoma
  • open to healthy people ages 20-85

• Comparing Rate Response With CLS Versus Accelerometer ICD Settings in Heart Failure Patients With BIOTRONIK CRT-Ds

  • study on Heart Failure and ICD
  • open to healthy people ages 18-99

• Comparison of Preoperative Ultrasound Guided Pectoralis Nerve Block Placement/ Intra-operative Placement

  “Help us with research that we hope will lead to improved nerve blocks and increased patient satisfaction with their operative experience!”

  • study on Postoperative Pain
  • open to healthy females ages 18 years and up

• Comparison of the Cosmetic Effects of Bakuchiol and Retinol

  • study on Wrinkles and Photoaging
  • open to healthy people ages 30-55

• CONNECT: Smoking Cessation and Lung Cancer Screening

  • study on Smoking Cessation and Lung Cancer
  • open to healthy people ages 55-80

• Consent for Use of Stored Patient Specimens for Future Testing

  • study on HIV/AIDS
  • open to healthy people

• Continuous Versus Cyclical OCP Use in PCOS

  • study on Polycystic Ovary Syndrome
  • open to healthy females ages 16-35

• Contrast-Enhanced MRI in Women With Ductal Breast Carcinoma in Situ and in Healthy Volunteers

  • study on Breast Cancer
  • open to healthy females ages 18 years and up

• Cooperative Huntington's Observational Research Trial

  • study on Huntington's Disease
  • open to healthy people

• Cue-Reward Learning and Weight Gain in Youth

  • study on Obesity
  • open to healthy people ages 8-11

• Daily Intake of Cocoa Flavanols and Arterial Stiffness in Humans

  • open to healthy people ages 25-65

• DECAMP-1: Diagnosis and Surveillance of Indeterminate Pulmonary Nodules

  • study on Lung Cancer
  • open to healthy people ages 45 years and up

• DECAMP-2: Screening of Patients With Early Stage Lung Cancer or at High Risk for Developing Lung Cancer

  • study on Pulmonary Disease and Lung Cancer
  • open to healthy people ages 50-79

• Dental Pulp Regeneration by Autologous Tissue Transplantation

  • study on Dental Pulp Regeneration
  • open to healthy people ages 7-50

• Determining Normal Range for Free Light Chains in Serum Among Twins

  • study on Multiple Myeloma
  • open to healthy people ages 18-80

• Developing Dynamic Theories for Behavior Change

  • study on Exercise
  • open to healthy people ages 18-65

• Diagnostic Innovations in Glaucoma Study

  • study on Glaucoma and Myopia
  • open to healthy people ages 18 years and up

• Dietary Treatment Study of Fat Synthesis and Risk of Cardiovascular Disease

  • study on Obesity and Weight Management
  • open to healthy people ages 20-65

• Digital Support Intervention on Newly Licensed Nurses

  • study on Stress and Job Stress
  • open to healthy people ages 19-37

• Does the Cap Increase the Finding of Polyps When Water Exchange Colonoscopy is Used

  • study on Colonoscopy and Colon Polyps
  • open to healthy people ages 50-75

• Dopaminergic Mechanisms Underlying Human Social Behavior

  • study on Decision Making and Executive Function
  • open to healthy people ages 18-40

• Double-Blind Randomized Controlled Trial for the Evaluation of a Novel Adaptive Attention Training in Healthy Adolescents

  • open to healthy people ages 12-16

• Drug-Drug Interaction Between Rifampin and Fluvastatin

  • study on Drug-drug Interaction
  • open to healthy people ages 18-65

• E-cigarettes and Blood Vessel Function

  • study on Nicotine Dependence
  • open to healthy people ages 21-45

• E-Cigarettes and SNA

  • study on Nicotine Dependence
  • open to healthy people ages 21-45

• E-cigarettes, Nicotine Inhaler, and Blood Vessel Function

  • study on Nicotine Dependence
  • open to healthy people ages 21-45

• Early vs. Interval Postpartum IUD Insertion

  • study on Contraception
  • open to healthy females ages 18 years and up

• Early-onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural Networks

  • study on Alzheimer's Disease and Dementia
  • open to healthy people ages 40-85

• ECigs, Inflammation and Oxidative Stress

  • study on E-cigarettes, Oxidative Stress, Inflammation
  • open to healthy people ages 21-45

• The Effect of 10-Week Exercise Training on Children With Asthma

  • study on Asthma
  • open to healthy people ages 8-35

• The Effect of Daily Mango Intake on Cardiovascular Health

  • study on Cardiovascular Risk Factor
  • open to healthy females ages 50-70

• Effect of Diastolic Dysfunction on Dynamic Cardiac Monitors

  • study on Stroke Volume Variation and Diastolic Dysfunction
  • open to healthy people ages 18 years and up

• The Effect of Gojiberry Intake (Lycium Barbarium) on Macular Function

  • study on Macular Pigment Optical Density
  • open to healthy people ages 45-65

• Effect of Paracervical Block Volume on Pain Control for Dilation and Curettage

  • study on Abortion
  • open to healthy females ages 18 years and up

• Effects of Brain Stimulation on Cognition, Oscillations and GABA Levels in Schizophrenia

  • study on Schizophrenia
  • open to healthy people ages 18-35

• Effects of Cannabis on Cognition and Endocannabinoid Levels in Bipolar Disorder Patients and Healthy Volunteers

  • study on Bipolar Disorder and Cannabis
  • open to healthy people ages 18-50

• Effects of Epicatechin on Statins for Mitochondrial Dysfunction and Impaired Exercise Capacity

  • study on Statin Intolerance
  • open to healthy people ages 30-75

• Effects of Epicatechin-rich Cocoa on Collagen Synthesis

  • study on Collagen Synthesis
  • open to healthy males ages 18-25

• The Effects of Exercise on Executive Functions

  • study on The Effects of Exercise on Executive Functions
  • open to healthy people ages 10-15

• Effects of Inflammation on Affect and Behavior

  • study on Anhedonia and Depression
  • open to healthy females ages 30-40

• Effects of Negative Affect in Individuals With Binge Eating Episodes

  • study on Bulimia Nervosa and Binge-Eating Disorder
  • open to healthy people ages 18-55

• Effects of Secondhand Smoke on Flight Attendant Health

  • study on Cardiopulmonary Disease
  • open to healthy people ages 18 years and up

• Effects of Short-term Diet on HDL Composition and Function

  • study on Diet Modification and HDL
  • open to healthy people ages 19-30

• The Effects of Sucrose-sweetened Beverage in African-American and Caucasian Women (SAAC) Study

  “In this study, we hope to learn about the metabolism of koolaid beverages that contain added sucrose (table sugar).”

  • open to healthy females ages 18-45

• The Effects of Transcranial Direct Current Stimulation (tDCS) on the Neuronal Mechanisms of Cognitive Control in Schizophrenia

  “Help us develop new treatments for patients who have difficulty with brain functions such as reasoning, including schizophrenic patients”

  • study on Schizophrenia
  • open to healthy people ages 18-35

• Electronic Hookah and Endothelial Cell Function

  • study on Smoking Cessation and Endothelial Dysfunction
  • open to healthy people ages 21-39

• Empower Korean Families to End Tobacco Use & Smoking Exposure

  • study on Smoking Cessation and Risk Reduction
  • open to healthy people ages 18 years and up

• Empower Opioid Misuse & Chronic Pain

  • study on Pain and Opioid Use
  • open to healthy people ages 18-75

• Endoscopic Surgery for Bariatric Revision After Weight Loss Failure

  • study on Obesity and Weight Loss
  • open to healthy people ages 18 years and up

• Engaging Mothers & Babies; Reimagining Antenatal Care for Everyone (EMBRACE) Study

  • study on Premature Birth and Pregnancy Preterm
  • open to healthy females

• Engaging Seronegative Youth to Optimize HIV Prevention Continuum

  • study on HIV/AIDS and Mental Health
  • open to healthy people ages 12-24

• Enhancing Memory Consolidation in Older Adults

  • study on Aging
  • open to healthy people ages 60-75

• Ethnic Influences on Stress, Energy Balance and Obesity in Adolescents

  • study on Obesity and Stress
  • open to healthy females ages 13-17

• Evaluating Multivariate MRI Maps of Body Awareness

  • study on Attention
  • open to healthy people ages 25-65

• Evaluating the Comparative Pharmacokinetics of Nicotine After Administration Via JUUL or Tobacco Cigarettes

  • study on Nicotine Administration & Dosage and E-cigarettes
  • open to healthy people ages 21-70

• Evaluation of Abdominal Wall Block With Liposomal Bupivacaine for Post-Operative Analgesia in Donor Nephrectomy

  • study on Postoperative Pain and Analgesics, Opioid
  • open to healthy people ages 18 years and up

• Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men

  • study on Gonorrhea and Chlamydia
  • open to healthy males ages 18 years and up

• Evaluation of Multi-Organ Metabolism and Perfusion in NAFLD by Total Body Dynamic PET Scan on EXPLORER

  • study on Liver Disease and Steatohepatitis
  • open to healthy people ages 18 years and up

• Evaluation of Patient Outcomes From the Kidney Allograft Outcomes AlloSure Registry

  • study on Kidney Transplant
  • open to healthy people ages 18 years and up

• EXPLORER PET/CT in Healthy Volunteers

  • open to healthy people ages 18 years and up

• FA Clinical Outcome Measures

  • study on Friedreich's Ataxia and Neurodegenerative Disease
  • open to healthy people ages 4-80

• FACE-PC: Family-Centered Care for Older Adults With Depression and Chronic Medical Conditions in Primary Care

  • study on Chronic Medical Conditions and Depression
  • open to healthy people ages 60 years and up

• Feasibility of a Single-operator Peroral Cholangiopancreatioscopy System (SpyGlass)

  • study on Bile Duct Strictures and Common Bile Duct Stones
  • open to healthy people ages 18 years and up

• FemBloc® Contraception Pivotal Trial

  • study on Contraception
  • open to healthy females ages 21-45

• Fetal Intervention for Aortic Stenosis and Evolving Hypoplastic Left Heart Syndrome

  • study on Aortic Stenosis and Hypoplastic Left Heart Syndrome
  • open to healthy females ages 16 years and up

• Fiber Study

  “The purpose of this study is to determine if dietary fiber increases overall gut health”

  • study on Gut Microbiome
  • open to healthy people ages 18-45

• Fibroblast Specific Inhibition of LOXL2 and TGFbeta1 Signaling in Patients With Pulmonary Fibrosis.

  • study on Fibrosis and Idiopathic Pulmonary Fibrosis
  • open to healthy people ages 40-70

• Financial Incentives and Text Messaging to Improve African American Womens' Glycemic Control

  • study on Diabetes
  • open to healthy females ages 25-65

• Flushing Reduction Associated With Nitrates

  • study on Hot Flashes
  • open to healthy females ages 40-62

• Gas Exchange Kinetics and Work Load During Exercise

  • study on Methods of Exercise
  • open to healthy people ages 7-35

• Guided Meditation and Stress-Induced Eating

  • study on Stress-induced Eating
  • open to healthy people ages 18 years and up

• Habitual Diet and Avocado Trial

  • study on Intra-abdominal Fat and Metabolic Syndrome
  • open to healthy people ages 25 years and up

• Have heavy menstrual bleeding? Participate in a research study to test an intrauterine device (IUD) treatment.

  “We're evaluating if an IUD is safe and effective in helping women with heavy periods”

  • study on Menorrhagia
  • open to healthy females ages 18-50

• Healing Our Hearts Minds and Bodies: CVD Reduction in Persons With HIV

  • study on HIV/AIDS and Cardiovascular Risk Factor
  • open to healthy people ages 18 years and up

• The Healthy Heroes Study

  • study on Shift Workers' Health and Time Restricted Eating
  • open to healthy people ages 21-65

• Heart and Lung Function Monitoring System

  • study on Heart Disease and Lung Diseases
  • open to healthy people ages 18 years and up

• Helping Families Pilot of a Family Resilience Program for Families Experiencing Homelessness and Parental Substance Use

  • study on Family Relationship and Coping Skills
  • open to healthy people ages 8 years and up

• HOPE Social Media Intervention for HIV Testing and Studying Social Networks

  • study on HIV/AIDS
  • open to healthy males ages 18-89

• Hormonal Mechanisms of Sleep Restriction - Axis Study

  • study on Sleep Restriction
  • open to healthy males ages 22-45

• Hormonal Mechanisms of Sleep Restriction - Axis Study in Older Men and Postmenopausal Women

  • study on Sleep Restriction
  • open to healthy people ages 60-80

• Identifying Biological Markers for Severe Depression

  • study on Depression
  • open to healthy people ages 18-70

• iKanEat: A Randomized-controlled, Multi-center Trial of Megestrol for Chronic Oral Food Refusal in Children

  • study on Feeding Behavior and Feeding Disorder of Infancy or Early Childhood
  • open to healthy people ages 9 months to 66 months

• Imaging Innovations for Placental Assessment in Response to Environmental Pollution (PARENTs)

  • study on Placental Disease
  • open to healthy females ages 18 years and up

• Immune-Related Trafficking and Signaling in Human Skin Associated With Low-Power, Infrared Laser Treatment

  • study on Vaccine Response Impaired
  • open to healthy people ages 18-50

• The Impact of 8 Weeks of a Digital Meditation Application on Work Stress

  • study on Stress and Psychological
  • open to healthy people ages 18 years and up

• The Impact of 8 Weeks of Digital Meditation Application and Healthy Eating Program on Work Stress and Health Outcomes

  • study on Stress and Psychological
  • open to healthy people ages 18 years and up

• Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace

  • study on Smoking Cessation and Tobacco
  • open to healthy people ages 21 years and up

• Improving HPV Vaccination Rates Among Rural and Native American Adolescents

  • study on Human Papillomavirus
  • open to healthy people ages 11-17

• Improving the Diagnosis of Common Variable Immune Deficiency

  • study on CVI - Common Variable Immunodeficiency
  • open to healthy people

• In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment

  • study on Dementia and Mild Cognitive Impairment
  • open to healthy people ages 18 years and up

• In-Home Technology for Dementia Caregivers

  • study on Dementia and Alzheimer's Disease
  • open to healthy people ages 18 years and up

• Independent Walking for Brain Health

  • study on Exercise and Aging
  • open to healthy people ages 65-80

• Inferior Vena Cava (IVC) Diameters Before & After Interscalene Block

  • study on IVC - Inferior Vena Cava Abnormality
  • open to healthy people ages 18 years and up

• Inflammation and Threat Sensitivity in PTSD

  • study on Post-Traumatic Stress Disorders
  • open to healthy people ages 30-60

• Inflammation, Diabetes, Ethnicity and Obesity Cohort

  • study on Obesity and Diabetes
  • open to healthy people ages 25-65

• Influence of Freeze Dried Strawberry Consumption on Gut Microbiota and Cardiovascular Health.

  • study on Microbial Colonization and Cardiovascular Disease
  • open to healthy people ages 40-65

• Influence of Reward and Punishment on Goal-directed and Habit Learning in Adolescent Anorexia Nervosa

  • study on Anorexia
  • open to healthy females ages 13-17

• Injectable DMAU for Male Contraception in Healthy Male Volunteers (CCN015)

  • study on Contraception
  • open to healthy males ages 18-50

• Integrating Behavioral Treatment in Primary Care

  • study on Parent-Child Relations
  • open to healthy people ages 2-10

• Internet-based CBT for Tinnitus

  • study on Tinnitus
  • open to healthy people ages 18 years and up

• Interventions To Help Asthma Clinical Adherence

  • study on Asthma and Hispanic Americans
  • open to healthy people ages 5-17

• Investigating the Cardiovascular Toxicity of Exposure to Electronic Hookah Vaping

  • study on Smoking Cessation and Endothelial Dysfunction
  • open to healthy people ages 21-39

• Investigating the Effect of Single-session Sauna Use on Body Temperature

  • study on Core Body Temperature 101.3 F
  • open to healthy people ages 18-45

• Join a research study of a potential new form of birth control

  “Help us understand if an investigational vaginal ring is safe and effective in preventing pregnancy”

  • study on Contraception
  • open to healthy females ages 18-35

• Kidney Awareness Registry and Education

  • study on Kidney Disease
  • open to healthy people ages 18-75

• Labyrinth Intervention in High-Fidelity Long-Term Memory

  • study on Long-Term Memory Decline and Mild Cognitive Impairment
  • open to healthy people ages 62-85

• Leucine for Depression Study (L-DEP)

  • study on Depression
  • open to healthy people ages 18-65

• Linkage of Transgender Individuals to PrEP

  • study on HIV/AIDS and Linkage
  • open to healthy people ages 18 years and up

• Liver Fat and Iron Quantification MRI

  • study on Liver Disease
  • open to healthy people ages 18 years and up

• Longitudinal Early-onset Alzheimer's Disease Study Protocol

  • study on Alzheimer's Disease and Mild Cognitive Impairment
  • open to healthy people ages 40-64

• Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects

  • study on Dementia
  • open to healthy people ages 18-90

• Longitudinal Performance of Epi proColon

  • study on Colorectal Cancer
  • open to healthy people ages 50-74

• Maternal Emotions and Diet in Pregnancy

  • study on Pregnancy and Stress, Psychological
  • open to healthy females ages 18-40

• MDMA in Subjects With Moderate Hepatic Impairment and Subjects With Normal Hepatic Function

  • study on Pharmacokinetics and Hepatic Impairment
  • open to healthy people ages 18-65

• Measuring Brain Inflammation in Autism

  • study on Autism
  • open to healthy males ages 18-35

• Medication Abortion Via Pharmacy Dispensing

  • study on Pregnancy and Abortion
  • open to healthy females ages 15 years and up

• Memantine Effects on Sensorimotor Gating and Neurocognition in Schizophrenia

  • study on Schizophrenia and Schizo Affective Disorder
  • open to healthy people ages 18-50

• Metabolic Effects of Sugar and Aspartame

  “What are the effects of consuming sugar- and aspartame-sweetened beverages with standardized diets?”

  • study on Chronic Disease of Cardiovascular System and Diabetes
  • open to healthy people ages 18-40

• Metformin, Vitamin D, and Depression in Polycystic Ovary Syndrome (PCOS) Trial

  • study on Polycystic Ovary Syndrome and Depression
  • open to healthy females ages 18-45

• Methylsulfonylmethane on Knee Laxity

  • study on Ligament Injury and Tendon Rupture
  • open to healthy females ages 18-30

• Microbiologic Alterations of the Conjunctiva of Hot Tub-soaking Ophthalmologists

  • study on Conjunctivitis, Bacterial and Keratitis Bacterial
  • open to healthy people ages 18 years and up

• Minimally Invasive Thoracic Surgery Intercostal Nerve Block Trial

  • study on Thoracic Diseases and Postoperative Pain
  • open to healthy people ages 18 years and up

• Mobile Web-based Behavioral Intervention for Improving Caregiver Well-being

  • study on Depression and Stress, Psychological
  • open to healthy people ages 40 years and up

• Modafinil Effects on EEG Biomarkers of Reward and Motivation

  • open to healthy people ages 18-35

• MRI and PET Biomarkers for Cognitive Decline in Older Adults

  • study on Alzheimer's Disease and Cognitive Impairment
  • open to healthy people ages 60-85

• Multimodal MRI Characteristics of Psychotherapy Response in Late Life Depression

  • study on Depression
  • open to healthy people ages 65 years and up

• Multimodal Sleep Pathway for Shoulder Arthroplasty

  • study on Sleep Disorders and Arthritis
  • open to healthy people ages 18 years and up

• N-Acetyl Cysteine Protects Pulpal Stem Cells in Endodontic Revascularization

  • study on Endodontic Disease
  • open to healthy people ages 6-18

• The NanoStrand Clinical Study

  • open to healthy people ages 18-80

• Near Infrared Spectroscopy (NIRS) for Assessment of Depression

  • study on Depression
  • open to healthy people ages 18 years and up

• Need Emergency Contraception? Participate in a research study.

  “We want to find out which morning-after pill is most effective in women who weigh 176 pounds or more”

  • study on Contraception
  • open to healthy females ages 18-40

• Network Of Clinical Research Studies On Craniosynostosis, Skull Malformations With Premature Fusion Of Skull Bones

  • study on Craniosynostosis
  • open to healthy people ages up to 80 years

• Neural Mechanisms of Meditation Training in Healthy and Depressed Adolescents: An MRI Connectome Study

  • open to healthy people ages 14-18

• North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)

  • study on Mitochondrial Disorders and Mitochondrial Genetic Disorders
  • open to healthy people

• Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry

  • study on Rheumatic Joint Disease
  • open to healthy people ages 2-21

• THE OMEGA-SPM-DOSE and OMEGA-SPM-PAD: Specialized Pro-Resolving Mediators in Patients With Peripheral Artery Disease

  • study on Peripheral Arterial Disease and Claudication
  • open to healthy people

• Optical Coherence Tomography (OCT) Reference Data Collection Study (S-2015-1)

  • study on Glaucoma
  • open to healthy people ages 18-90

• Optical Coherence Tomography (OCT) Reference Data Collection Study (S-2015-3)

  • study on Glaucoma
  • open to healthy people ages 18-90

• Oral Bacterial Extract for the Prevention of Wheezing Lower Respiratory Tract Illness

  • study on Asthma and Wheezing
  • open to healthy people ages 6 months to 18 months

• OTIS Autoimmune Diseases in Pregnancy Project

  • study on Crohn's Disease and Inflammatory Bowel Disease
  • open to healthy females

• Ovarian Response to Recombinant Follicle Stimulating Hormone in Women With PCOS

  • study on Polycystic Ovary Syndrome and Anovulation
  • open to healthy females ages 18-37

• Paracervical Block Volume and Pain Control During Dilation and Curettage

  • study on Abortion and Pain Uterus
  • open to healthy females ages 18 years and up

• The Parkinson's Genetic Research Study

  • study on Parkinson's Disease
  • open to healthy people ages 18 years and up

• The Pathogenesis of OSA in People Living With HIV

  • study on Sleep Apnea and Sleep Disorders
  • open to healthy people ages 40-79

• Pathophysiology of the Upper Airway in Patients With COPD and Concomitant OSA

  • study on Sleep Apnea and Sleep Disorders
  • open to healthy people ages 40-70

• Patient Portal and Navigation Program in Providing Information for Asian American Cancer Patients

  • study on Caregivers and Malignant Neoplasm
  • open to healthy people ages 21 years and up

• Pay For Success: Permanent Supportive Housing for the Chronically Homeless

  • study on Homelessness
  • open to healthy people ages 18 years and up

• Peripheral Nerve Blocks for Major Lower Extremity Amputations

  • study on Postoperative Pain
  • open to healthy people ages 18 years and up

• Personal Responsibility Education Program Innovative Strategies: Digital Initiative for Youth

  • study on Reproductive Health and Contraception
  • open to healthy people ages 13-19

• Personalized HIV and STI Testing Tool

  • study on Risk Reduction and HIV/AIDS
  • open to healthy males ages 18-29

• PET Imaging of Radiolabeled Anti-HIV-1 Envelope Monoclonal Antibody (VRC01)

  • study on HIV/AIDS
  • open to healthy people ages 18 years and up

• Pharmacokinetics of Advantage Arrest in Children

  • study on Dental Caries
  • open to healthy people ages 3-13

• Pharmacologically-augmented Cognitive Therapies (PACTs) for Schizophrenia.

  • study on Schizophrenia
  • open to healthy people ages 18-55

• Phono- and Electrocardiogram Assisted Detection of Valvular Disease

  • study on Aortic Stenosis and Mitral Valve Insufficiency
  • open to healthy people ages 18 years and up

• Pilot Human Laboratory Study of Alcohol Approach Bias Modification (AABM) for AUD

  • study on Alcohol Use
  • open to healthy males ages 21-50

• Post-Injury Platelet Biology: Mechanisms and Outcomes

  • study on Wound and Injuries and Blood Platelets
  • open to healthy people ages 18 years and up

• Postoperative Management of Groin Flaps for Vascular Coverage

  • study on Wound Complication
  • open to healthy people ages 18 years and up

• Postpartum Care Timing: A Randomized Trial

  • study on Postpartum and Pregnancy
  • open to healthy females ages 18-50

• Prevention of Adolescent Risky Behaviors: Neural Markers of Intervention Effects

  • study on Risk-Taking and Adolescent Behavior
  • open to healthy people ages 11-14

• Prevention Support for People Leaving Jail

  • study on HIV/AIDS and Sexually Transmitted Infections
  • open to healthy males ages 18-44

• Progression and Etiology of Cortical Porosity in Diabetic Bone Disease

  • study on Diabetes and Diabetes Type 2
  • open to healthy people ages 50-70

• Proof of Mechanism Study for the Treatment of Social Anhedonia in ASD

  • study on Atrial Septal Defect
  • open to healthy people ages 13-30

• PTSD Training for PCPs in a Virtual World

  • study on Post-Traumatic Stress Disorders
  • open to healthy people

• Radiofrequency Ablation (heat therapy to reduce nerve pain) For Vertebral Compression Fracture Pain

  • study on Vertebral Compression Fracture and Facet Joint Pain
  • open to healthy people ages 18-90

• Reducing Breast Cancer Risk in Korean American Women

  • study on Tobacco and Breast Cancer
  • open to healthy people ages 18 years and up

• Reducing Pesticide Exposures

  • study on Risk Reduction and Environmental Exposure
  • open to healthy people ages 3-75

• Reinforced Enhanced - Families Responsibility Education Support and Health

  • study on Obesity
  • open to healthy people ages 7-12

• Relative Mitochondrial Toxicity of Tenofovir Alafenamide (TAF) vs. Tenofovir Disoproxil Fumarate (TDF)

  • study on HIV/AIDS and Antiviral Toxicity
  • open to healthy people ages 18-80

• Retinal Imaging in Patients With Inherited Retinal Degenerations

  • study on Retinitis Pigmentosa
  • open to healthy people ages 13 years and up

• Rifaximin Soluble Solid Dispersion (SSD) Tablets Plus Lactulose for the Treatment of Overt Hepatic Encephalopathy (OHE)

  • study on Overt Hepatic Encephalopathy
  • open to healthy people ages 18-75

• Role of Angiogenesis in Dermatologic Diseases: A Potential Therapeutic Target

  • study on Dermatologic Diseases
  • open to healthy people ages 18 years and up

• Safety and Efficacy of Deoxycholic Acid Injection for Reduction of Upper Inner Thigh Fat

  • study on Adiposity
  • open to healthy people ages 18-65

• Safety and Efficacy Study of Injectable Cabotegravir Compared to Daily Oral Tenofovir Disoproxil Fumarate/Emtricitabine (TDF/FTC), For Pre-Exposure Prophylaxis in HIV-Uninfected Cisgender Men and Transgender Women Who Have Sex With Men

  • study on HIV/AIDS
  • open to healthy people ages 18 years and up

• Safety and Immunogenicity of a Single Dose of the Recombinant Live-Attenuated Respiratory Syncytial Virus (RSV) Vaccines RSV ΔNS2/Δ1313/I1314L, RSV 6120/ΔNS2/1030s, RSV 276 or Placebo, Delivered as Nose Drops to RSV-Seronegative Children 6 to 24 Months of Age

  • study on Respiratory Syncytial Virus (RSV)
  • open to healthy people ages 6 months to 25 months

• The Safety and Intake Rate of a Natural Compound Arctigenin in Healthy Men

  • open to healthy males ages 20-75

• Say When: Targeting Heavy Alcohol Use With Naltrexone Among MSM

  • study on Alcohol Use and HIV/AIDS
  • open to healthy males ages 18-70

• Sedentary Behavior Interrupted Randomized Controlled Trial (P2)

  • study on Sedentary Lifestyle
  • open to healthy females ages 55 years and up

• Sedentary Behavior Interrupted: A Trial of Acute Effects on Biomarkers of Healthy Aging

  • study on Sedentary Lifestyle
  • open to healthy females ages 55 years and up

• Sensory Enrichment for Older Adults

  • study on Cognition
  • open to healthy people ages 60-85

• Service and Health Among Deployed Veterans

  • study on Pulmonary Function
  • open to healthy people

• Shape Up! Kids Study

  • open to healthy people ages 5-17

• The Share Health Study: Teen Social Connections and Health (Phase 2)

  • study on Contraception
  • open to healthy females ages 15-20

• Short-Term Cardiovascular Effects of E-Cigarettes: Influence of Device Power

  • study on Cardiovascular Risk Factor and Nicotine Dependence
  • open to healthy people ages 21 years and up

• Single Cell Genomics of Psoriatic Skin

  • study on Psoriasis
  • open to healthy people ages 18 years and up

• Sleep and Healthy Aging Research for Depression (SHARE-D) Study

  • study on Depression
  • open to healthy people ages 60-90

• SMART 2.0: Social Mobile Approaches to Reducing weighT in Young Adults

  • study on Obesity and Weight Management
  • open to healthy people ages 18-35

• Smoking and Ventricular Repolarization

  • study on Sudden Cardiac Death and Prolonged QTc Interval
  • open to healthy people ages 21-45

• Social Engagement Strategies to Improve Medication Adherence

  • study on Diabetes and Atherosclerosis
  • open to healthy people ages 50 years and up

• Social Experiences and Sleep Study

  • study on Sleep and Blood Pressure
  • open to healthy people ages 18-62

• Sorting and Expression Profiling of Airway Cells From Humans (The SEARCH Study)

  • study on Asthma
  • open to healthy people ages 18-70

• Southern California Nutrition Incentive Program

  • study on Food Insecurity
  • open to healthy people ages 18 years and up

• Sperm Selection by Microfluidic Separation Improves Embryo Quality in Patients With a History of Poor Embryo Quality

  • study on Sperm DNA Fragmentation and Embryo Quality
  • open to healthy people ages 18-65

• Standard Endoscopic Hemostasis Versus OVESCO Severe Non-variceal UGI Hemorrhage

  • study on Upper Gastrointestinal Hemorrhage
  • open to healthy people ages 18-100

• Stepped Care for Youth Living With HIV

  • study on HIV/AIDS and Mental Health
  • open to healthy people ages 12-24

• Strategy to Prevent the Onset of Clinically-Apparent Rheumatoid Arthritis

  • study on Arthritis and Rheumatoid Arthritis
  • open to healthy people ages 18 years and up

• Stress Free UCR: The Impact of 8 Weeks of Headspace on Stress in a Heterogeneous University Employee Cohort

  • study on Stress, Psychological
  • open to healthy people ages 18 years and up

• Study Comparing the Effects of Latanoprostene Bunod and Timolol on Retinal Blood Vessel Density and Visual Acuity

  • study on Glaucoma and High Blood Pressure
  • open to healthy people ages 40-90

• Study of Adjuvant Ipilimumab and Nivolumab in Subjects With High-risk Ocular Melanoma

  • study on Melanoma and Skin Cancer/Melanoma
  • open to healthy people ages 18 years and up

• Study of Daily Application of Nestorone® (NES) and Testosterone (T) Combination Gel for Male Contraception

  • study on Men and Contraception
  • open to healthy people ages 18-50

• Study of Food Aversion in Patients With Anorexia Nervosa

  • study on Anorexia
  • open to healthy females ages 18-55

• Study of Spermatogenesis Suppression With DMAU Alone or With LNG Versus Placebo Alone in Normal Men

  • study on Men and Contraception
  • open to healthy males ages 18-50

• Study of the Inflammation and Airway Changes That Occur After Exposure to Allergen in Asthmatics

  • study on Asthma
  • open to healthy people ages 18-50

• Study to examine if video self review of intubation skills by medical students help them learn the skill faster

  “Video of medical students performing intubation on patients to aid in their education and competency of this skill”

  • study on Surgery
  • open to healthy people

• Study to Understand Gaining Access to Blood Glucose Records

  • study on Diabetes
  • open to healthy people ages 18 years and up

• Summertime: Kids in Motion

  • study on Sleep
  • open to healthy people ages 8-10

• Surveillance Monitoring for ART Toxicities Study in HIV Uninfected Children Born to HIV Infected Women

  • study on Antiretroviral Toxicity
  • open to healthy people

• Tau Imaging With JNJ067

  • study on Alzheimer's Disease and Mild Cognitive Impairment
  • open to healthy people ages 50 years and up

• Therapeutic Rest in Early Labor, A Study on Morphine Sleep.

  • study on Labor Pain and Early Labor
  • open to healthy females ages 18-55

• Tissue-specific Insulin Resistance in Obstructive Sleep Apnea: Role of Hypoxia

  • study on Sleep Apnea and Sleep Disorders
  • open to healthy people ages 40-70

• Topical Antibiotic Prophylaxis for Eyelids

  • study on Antibiotics and Eyelid Diseases
  • open to healthy people ages 18 years and up

• Training to Enhance Cognition in Older Adults

  • study on Cognitive Enhancement and Aging
  • open to healthy people ages 60-80

• Trans-MAPP II Study of Urologic Chronic Pelvin Pain

  • study on Interstitial Cystitis and Chronic Prostatitis
  • open to healthy people ages 18 years and up

• Transcranial Direct Current Stimulation (tDCS) as a Treatment for Acute Fear

  • study on Fear
  • open to healthy people ages 21-65

• Transcranial Electrical Stimulation for mTBI

  • study on Brain Injuries and Concussion
  • open to healthy people ages 18-60

• Transfusion Trigger After Operations in High Cardiac Risk Patients

  • study on Myocardial Infarction and Coronary Revascularization
  • open to healthy people ages 18 years and up

• Translating Evidence-based Interventions for Autism: Multi-Level Implementation Strategy

  • study on Autism
  • open to healthy people ages 18 years and up

• Transseptal vs Retrograde Aortic Ventricular Entry to Reduce Systemic Emboli

  • study on Neurocognitive Dysfunction
  • open to healthy people ages 18 years and up

• TRC-PAD Program: In-Clinic Trial-Ready Cohort

  • study on Alzheimer's Disease and Dementia
  • open to healthy people ages 50-85

• TREAT-BE Study (Treatment With Resection and Endoscopic Ablation Techniques for Barrett's Esophagus)

  • study on Barrett's Esophagus and Esophageal Cancer
  • open to healthy people ages 18-100

• Treating Phobia With Multivoxel Neuro-reinforcement

  • study on Phobia
  • open to healthy people ages 18-65

• Treatment for Patients With Chronic Post-Concussion Symptoms

  • study on Brain Injuries and Concussion
  • open to healthy people ages 13-25

• Trial to Reduce Sitting Time in Postmenopausal Latina Women at Increased Risk for Heart Disease

  • study on Sedentary Lifestyle
  • open to healthy females ages 55 years and up

• TrialNet Pathway to Prevention of T1D

  • study on Diabetes and Diabetes Type 1
  • open to healthy people ages 30 months to 45 years

• Urinary Biomarkers of OI Pathobiology

  • study on Osteogenesis Imperfecta
  • open to healthy people

• Use of a Distal Colonoscope Attachment to Increase Detection of Sessile Serrated Adenomas

  • study on Sessile Serrated Adenoma
  • open to healthy people ages 45-85

• The Use of Lymph Node Biopsies to Support HIV Pathogenesis Studies

  • study on HIV/AIDS
  • open to healthy people ages 18-70

• The Use of Virtual Reality to Reduce Anxiety and Pain in Perioperative Settings

  • study on Perioperative Pain and Perioperative Anxiety
  • open to healthy people ages 18-75

• Using a Field Performance Test on an iPad to Evaluate Driving Under the Influence of Cannabis

  • study on Cannabis
  • open to healthy people ages 21-55

• Utility of Donor-Derived Cell Free DNA in Association With Gene Expression Profiling

  • study on Cardiac Transplant Failure and Cardiac Transplant Rejection
  • open to healthy people ages 15 years and up

• Vagal Nerve Stimulation to Probe Inflammation and Brain in Post-traumatic Stress

  • study on Post-traumatic Stress
  • open to healthy males ages 21-65

• Validating Cardiac MRI Biomarkers and Genotype-Phenotype Correlations for DMD

  • study on Duchenne Muscular Dystrophy
  • open to healthy males ages 7-21

• Validation of an Automated Online Language Interpreting Tool - Phase Two.

  • study on Mood Disorder and Anxiety Disorders
  • open to healthy people ages 18 years and up

• Validation of Bladder Health Instrument for Evaluation in Women

  • study on Lower Urinary Tract Symptoms
  • open to healthy females ages 18 years and up

• Vaping THC From Electronic Cigarettes

  • study on Cannabis
  • open to healthy people ages 21-70

• VDOT for Monitoring Adherence to LTBI Treatment

  • study on Tuberculosis
  • open to healthy people ages 13 years and up

• Vestibular Stimulation to Trigger Adipose Loss (VeSTAL) Clinical Trial

  • study on Obesity
  • open to healthy people ages 22-80

• Walnut Study

  “Postmenopausal Women Needed for a Research Study”

  • study on Obesity and Weight Management
  • open to healthy females ages 45-65

• The WISDOM Study (wisdomstudy.org)

  “What is the best mammogram screening schedule for women? Clinical experts disagree. Help us find out!”

  • study on Breast Cancer
  • open to healthy females ages 40-74

• Within-Breath Total Respiratory Input Impedance in Healthy Adult Subjects

  • study on Respiratory Disease
  • open to healthy people ages 18 years and up