Aortic Stenosis clinical trials at University of California Health
7 in progress, 5 open to eligible people
ACURATE IDE Study: Safety and Effectiveness of the Experimental Acurate Valve for Transcatheter Aortic Valve Replacement
open to all eligible people
To evaluate safety and effectiveness of the ACURATE Transfemoral Aortic Valve System for transcatheter aortic valve replacement (TAVR) in subjects with severe native aortic stenosis who are indicated for TAVR.
at UC Davis
Aortic Valve Replacement Without Major Surgery for Patients With Aortic Stenosis (Narrowing of the Aortic Heart Valve)
“You are being considered for this research study because you have severe aortic stenosis (narrowing of the aortic valve) without symptoms.”
open to eligible people ages 65 years and up
This clinical trial is a prospective, randomized, controlled, multi-center study. Patients will be randomized 1:1 to receive either transcatheter aortic valve replacement (TAVR) with the Edwards SAPIEN 3 / SAPIEN 3 Ultra THV or clinical surveillance. Patients will be stratified by whether or not they are able to perform a treadmill stress test. Patients who have a positive stress test will be followed in a registry to collect data on subsequent treatment and mortality, as applicable.
at UC Davis
Fetal Intervention for Aortic Stenosis and Evolving Hypoplastic Left Heart Syndrome
open to eligible females ages 16 years and up
For fetuses with severe aortic stenosis, in utero balloon aortic valvuloplasty may improve fetal growth of left heart structures and thus improve potential for biventricular repair strategies after birth.
at UCSF
PARTNER 3 Trial - Aortic Valve-in-Valve
open to all eligible people
This study will assess the safety and effectiveness of the SAPIEN 3 transcatheter heart valve in patients with a failing aortic surgical or transcatheter bioprosthetic valve.
at UCLA
Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)
open to eligible people ages 18 years and up
The objective of this study is to determine the safety and efficacy of transcatheter aortic valve replacement (TAVR) via a transfemoral approach in HF patients with moderate AS as compared with OHFT.
at UCLA UCSD
PARTNER 3 Trial: Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis
Sorry, in progress, not accepting new patients
To establish the safety and effectiveness of the Edwards SAPIEN 3 Transcatheter Heart Valve in patients with severe, calcific aortic stenosis who are at low operative risk for standard aortic valve replacement (AVR).
at UCLA
Surgical Treatment of Aortic Stenosis With a Next Generation, Rapid Deployment Surgical Aortic Valve
Sorry, in progress, not accepting new patients
The purpose of the clinical study is to prove that the heart valve device is safe, effective, and performs as intended.
at UCLA
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