Cardiac Arrest clinical trials at University of California Health

7 in progress, 6 open to eligible people

Showing trials for

  • Cardiac Sympathetic Denervation for Prevention of Ventricular Tachyarrhythmias

    open to eligible people ages 18 years and up

    The purpose of this research study is to examine the effect of cardiac sympathetic denervation (CSD) surgery on life threatening abnormal heart rhythms called ventricular tachycardia or ventricular fibrillation that can lead to sudden cardiac death. Subjects will be asked to participate in this research study if they have recurrent ventricular tachycardia (at least one ICD shock for ventricular tachycardia) and have undergone at least one catheter ablation procedure or have ventricular tachycardia or fibrillation that is not ablatable. The goal of this study is to determine whether cardiac sympathetic denervation can prevent these abnormal heart rhythms from occurring and therefore, prevent, ICD shocks which are not only painful, but have been shown to reduce quality of life and/or lead to depression, particularly in the period immediately after the shock.

    at UCLA

  • Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients

    open to eligible people ages 18 years and up

    A multicenter, randomized, adaptive allocation clinical trial to determine if increasing durations of induced hypothermia are associated with an increasing rate of good neurological outcomes and to identify the optimal duration of induced hypothermia for neuroprotection in comatose survivors of cardiac arrest.

    at UC Davis UCLA UCSD UCSF

  • Optimization of VNS in Epileptic Patients to Induce Cardioprotection

    open to eligible people ages 18 years and up

    This study is a non-randomized, prospective study in patients with a diagnosis of epilepsy and previously implanted FDA approved Vagus Nerve Stimulation (VNS) devices. The goal of this clinical investigation is to evaluate the effects of adjusting vagus nerve stimulation parameters to engage cardioprotective effects.

    at UCLA

  • Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)

    open to eligible people ages up to 17 years

    This is a multicenter trial to establish the efficacy of cooling and the optimal duration of induced hypothermia for neuroprotection in pediatric comatose survivors of cardiac arrest. The study team hypothesizes that longer durations of cooling may improve either the proportion of children that attain a good neurobehavioral recovery or may result in better recovery among the proportion already categorized as having a good outcome.

    at UC Davis UCLA UCSF

  • Smoking and Ventricular Repolarization

    open to eligible people ages 21-45

    Randomized controlled trial of acute use of electronic cigarette or tobacco cigarette on parameters of ventricular repolarization.

    at UCLA

  • The Role of Electrophysiology Testing in Survivors of Unexplained Cardiac Arrest

    open to all eligible people

    Sudden cardiac death (SCD) remains a major cause of mortality within developed nations despite aggressive efforts to reduce its societal burden. Despite extensive clinical and genetic investigations, a subgroup of cardiac arrests remain unexplained, highlighting the potential contribution of additional cardiac conditions that may not be identified with contemporary diagnostic algorithms. The EPS ARREST study aims to evaluate the role of invasive electrophysiology study within this patient population.

    at UCLA UCSD UCSF

  • RESTORE: buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest

    Sorry, not yet accepting patients

    RESTORE is a randomized clinical trial investigating the safety and feasibility of using EEG treatment targets (burst suppression vs. seizure suppression) for post-cardiac arrest refractory status epilepticus treatment.

    at UCSF

Our lead scientists for Cardiac Arrest research studies include .

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