Skip to main content

Danon Disease clinical trials at University of California Health

4 in progress, 3 open to eligible people

Showing trials for
  • Gene Therapy Study of RP-A501 in Male Patients With Danon Disease

    open to eligible males ages 8 years and up

    This is a single arm Phase 2 trial to evaluate the efficacy and safety of RP-A501, a recombinant adeno-associated virus serotype 9 (AAV9) containing the human lysosome-associated membrane protein 2 isoform B (LAMP2B) transgene, in male patients with Danon Disease.

    at UCSD

  • Danon Disease Natural History Study

    open to eligible males ages 8 years and up

    The goal of this international observational study is to learn about the natural history of Danon disease in male patients >8 years of age. The key objectives include assessing change over time in cardiac structure (left ventricular mass and wall thickness), cardiac biomarkers, symptoms, and quality of life and the incidence of clinical events such as HF hospitalization, cardiac transplantation, and death.

    at UCSD

  • Natural History of Danon Disease

    open to eligible people ages 0-100

    Danon disease (DD) is a rare, X-linked disorder associated with severe cardiomyopathy, and in many cases, skeletal myopathy, and cognitive impairment caused by mutations in the LAMP2 gene. There is still uncertainty regarding the natural history of DD because of its rarity. This study aims to determine the natural history of DD through the collection and analysis of retrospective and prospective data. To achieve this, the investigators will perform surveys and obtain medical records from DD patients. The same cohort of patients will also be assessed by a multidisciplinary team with expertise in DD (cardiologist, neurologist, ophthalmologist, psychologist, geneticist) at the University of California, San Diego. All patients with DD are eligible, including those who underwent a heart transplant. Additionally, data and records from deceased patients will provide valuable retrospective data for this study.

    at UCSD

  • Gene Therapy for Male Patients With Danon Disease (DD) Using RP-A501; AAV9.LAMP2B

    Sorry, in progress, not accepting new patients

    This is a non-randomized open-label Phase 1 study to evaluate the safety and toxicity of gene therapy using a recombinant adeno-associated virus serotype 9 (AAV9) containing the human lysosome-associated membrane protein 2 isoform B (LAMP2B) transgene (investigational product (IP), RP-A501) in male patients with Danon Disease (DD).

    at UCSD

Our lead scientists for Danon Disease research studies include .

Last updated: