Dravet Syndrome clinical trials at University of California Health
11 in progress, 2 open to eligible people
ETX101 in Infants and Children with SCN1A-Positive Dravet Syndrome
open to eligible people ages 6 months to 47 months
ENDEAVOR is a Phase 1/2, 2-part, multicenter study to evaluate the safety and efficacy of ETX101 in participants with SCN1A-positive Dravet syndrome aged ≥6 to <36 months (Part 1) and aged ≥6 to <48 months (Part 2). Part 1 follows an open-label,…
at UCSF
EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome
open to eligible people ages 2 years and up
The purpose of this study is to evaluate the safety and efficacy of EPX-100 as adjunctive therapy in participants with Dravet syndrome.
at UCSF
LP352 in Children and Adults With Dravet Syndrome (DS)
Sorry, not currently recruiting here
This (DEEp SEA Study) is a double-blind, randomized, placebo-controlled, multicenter study to investigate the efficacy, safety, and tolerability of LP352 in the treatment of seizures in children and adults with DS. The study consists of 3 main…
at UCLA
Soticlestat as an Add-on Therapy in Children and Adults With Dravet Syndrome or Lennox-Gastaut Syndrome
Sorry, in progress, not accepting new patients
The main aim of the study is to learn if soticlestat, when given as an add-on therapy, reduces the number of seizures in children and adults with Dravet Syndrome (DS) or Lennox-Gastaut Syndrome (LGS). Participants will receive their standard…
at UCLA UCSF
Soticlestat in Adults and Children With Rare Epilepsies
Sorry, in progress, not accepting new patients
The main aim is to assess the long-term safety and tolerability of soticlestat when used along with other anti-seizure treatment. Participants will receive soticlestat twice a day. Participants will visit the study clinic every 2-6 months throughout …
at UCLA
Long-Term Safety of ZX008 (Fenfluramine Hydrochloride) Oral Solution in Children and Adults With Epileptic Encephalopathy Including Dravet Syndrome and Lennox-Gastaut Syndrome
Sorry, in progress, not accepting new patients
This is an international, multicenter, open-label, long-term safety study of ZX008 in subjects with Dravet syndrome, Lennox-Gastaut syndrome or epileptic encephalopathy
at UCLA
STK-001 for Patients With Dravet Syndrome
Sorry, accepting new patients by invitation only
Stoke Therapeutics is evaluating the long-term safety & tolerability of repeated doses of STK-001 in patients with Dravet syndrome who previously participated in studies of STK-001. Change in seizure frequency and overall clinical status, and…
at UCSF
Fenfluramine in Children With Dravet Syndrome Under 24 Months of Age
Sorry, not currently recruiting here
Dravet syndrome is a genetic epilepsy associated with pathogenic variants in SCN1A that codes for Nav1.1, a protein necessary for sodium channels. Children with Dravet syndrome classically present in the first year of life with prolonged seizures,…
at UCSF
Access Program With Lorcaserin For The Treatment of Dravet Syndrome and Other Refractory Epilepsies
Sorry, not accepting new patients
The primary purpose of this study is to provide continued access of lorcaserin to participants with Dravet syndrome and other refractory epilepsies.
at UCLA
Intermediate-Size Expanded Access Protocol (EAP) for LP352
Sorry, not accepting new patients
This is an intermediate-size expanded access program (EAP) study. The purpose of this EAP is to provide continued access to LP352, an investigational drug product being investigated in participants with DEEs. The EAP study will allow continued…
at UCLA UCSF
Treatment of Dravet Syndrome With Fenfluramine (Expanded Access Protocol)
Sorry, not accepting new patients
The purpose of this research study is to (1) provide access to fenfluramine for patients with intractable epilepsy associated with Dravet syndrome, and (2) evaluate the safety of fenfluramine.
at UCLA
Our lead scientists for Dravet Syndrome research studies include Shaun A. Hussain, MD Rajsekar R. Rajaraman, MD, MS Ernesto Gonzalez-Giraldo, MD Joseph Sullivan.
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