Fuchs' Dystrophy clinical trials at University of California Health

4 in progress, 2 open to eligible people

Showing trials for

  • Descemet Endothelial Thickness Comparison Trial I

    open to eligible people ages 18 years and up

    Descemet Endothelial Thickness Comparison Trial (DETECT) I is a multi-center, outcome assessor-masked, placebo-controlled clinical trial randomizing 160 patients in a 2x2 factorial design. The purpose of this study is to determine differences in visual outcomes between two types of corneal transplant surgeries, ultrathin Descemet stripping automated endothelial keratoplasty (UT-DSAEK) and Descemet membrane endothelial keratoplasty (DMEK), and to determine the effect of rho-kinase inhibitors on endothelial cell loss.

    at UC Davis UCSF

  • Descemet Endothelial Thickness Comparison Trial II

    open to eligible people ages 18 years and up

    Descemet Endothelial Thickness Comparison Trial (DETECT) II is a multi-center, outcome assessor-masked, placebo-controlled clinical trial randomizing 60 patients with Fuchs endothelial dystrophy to DMEK versus Descemet Stripping Only (DSO) with adjunctive Ripasudil.

    at UC Davis UCSF

  • STN1010904 Ophthalmic Suspension 0.03% and 0.1% Compared With Vehicle in Subjects With Fuchs Endothelial Corneal Dystrophy (FECD)

    Sorry, in progress, not accepting new patients

    This is a Phase IIa study to assess efficacy and safety of STN1010904 ophthalmic suspension (0.03%, and 0.1 %), twice daily dosing when compared to Placebo in subjects diagnosed with Fuchs Endothelial Corneal Dystrophy (FECD). This study will consist of a Screening Period of up to 15 days and an 18-month Double-Masked Treatment Period, including 9 individual visits to the study site.

    at UCLA

  • K-321 Eye Drops After Descemetorhexis in Participants With Fuchs Endothelial Corneal Dystrophy (FECD)

    Sorry, in progress, not accepting new patients

    A study to assess the safety and efficacy of K-321 in participants with FECD after descemetorhexis.

    at UCLA

Our lead scientists for Fuchs' Dystrophy research studies include .

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