Hemorrhage clinical trials at University of California Health
2 in progress, 1 open to eligible people
Cold Stored Platelet in Hemorrhagic Shock
open to eligible people ages 15-90
The Cold Stored Platelet Early Intervention in Hemorrhagic Shock (CriSP-HS) trial is a proposed 3 year, open label, multi-center, randomized trial designed to determine the feasibility, efficacy, and safety of urgent release cold stored platelets (CSP) in patients in hemorrhagic shock. Patients will be randomized to receive either standard care or early infusion of urgent release cold stored platelets (CSP). The proposed pilot study will utilize 5 level-1 trauma centers from within the LITES network and will enroll approximately 200 patients. The primary outcome for the pilot trial is feasibility, with principal secondary clinical outcome of 24 hour mortality.
Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children: An Efficacy Study
Sorry, not yet accepting patients
Trauma is the leading cause of death and disability in children in the United States. The objective of this study is to evaluate the benefits and harms of tranexamic acid (TXA; a drug that stops bleeding) in severely injured children with hemorrhagic brain and/or torso injuries. Using thromboelastography, we will measure baseline fibrinolysis to assess for treatment effects of TXA at different levels of fibrinolysis.
at UC Davis
Our lead scientists for Hemorrhage research studies include Daniel K Nishijima, MD, MAS Lucy Kornblith, MD Nathan Kuppermann, MD, MPH.