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Inflammation clinical trials at UC Health
4 in progress, 1 open to eligible people

  • Effects of Short-term Diet on HDL Composition and Function

    open to eligible people ages 19-30

    The primary objective of this study is to generate preliminary data on the effects of a short-term diet of either fast food or Mediterranean type diet on HDL and microbiota composition and function in healthy subjects, which includes both normal weight and overweight/obese subjects.

    at UC Davis

  • Effects of Phytonutrients on Vascular Health and Skin in Obese Males

    Sorry, in progress, not accepting new patients

    This study will determine the effects of beneficial compounds of plant foods, such as pomegranate on cardiovascular health, skin inflammation and aging. This will be tested by asking healthy males to eat a high fat ground beef patty with 8oz. pomegranate juice or 8oz placebo (a study product that looks like pomegranate juice, but contains no active ingredients) and then measuring blood vessel dilation (endothelial function) by blood flow. The investigators also will measure the amount of Nitric Oxide (NO) in blood and urine samples and sugar and insulin in blood. In addition, a Cutometer, a device that measures the elasticity of the skin, will be used to obtain measurements of skin inflammation and aging. Healthy men have been chosen for this study because eating high fat hamburger patties can easily mimic in them the condition that causes atherosclerosis. The results from this study may help to explain how high fat foods can be harmful to the body and how beneficial plant foods can have on cardiovascular function and the skin.

    at UCLA

  • Inflammation and Daily Life Study

    Sorry, not yet accepting patients

    UCLA researchers looking for healthy individuals (age 45-60) to participate in a study investigating whether an anti-inflammatory medication can impact daily life, including mental and physical health, and the immune system. Everyday for four weeks, participants will take either an anti-inflammatory medication (naproxen) twice daily, or a placebo pill twice daily. Participants will also answer daily questions during the 4-week period. Participants will also come to the UCLA campus twice for blood draws, to fill out questionnaires, and complete a few tasks on the computer: once prior to the 4-week period and once immediately after the 4-week period.

    at UCLA

  • L-arginine in Severe Asthma Patients Grouped by Exhaled Nitric Oxide Levels

    Sorry, in progress, not accepting new patients

    The major impact of this study will be to identify the adult severe asthma cohort that will benefit from supplemental L-arginine therapy. The investigators hypothesize that a subset of adult severe asthma patients will respond to supplemental L-arginine and derive clinical benefit from the addition of this therapy to standard-of-care asthma medications. The investigators hypothesize that the patients that benefit most will have low exhaled nitric oxide concentrations (< 20 ppb) at baseline.

    at UC Davis

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