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Lumbar Spinal Stenosis clinical trials at UC Health
4 research studies open to eligible people

  • A Pivotal Study of the Premia Spine TOPS™ System

    open to eligible people ages 35-80

    The purpose of this trial is to assess whether the Total Posterior Spine System (TOPS System) is more effective than transforaminal lumbar interbody fusion (TLIF) when used to stabilize a single lumbar level (L2 - L5) following surgical decompression in patients diagnosed with (1) at least moderate lumbar spinal stenosis, and (2) Grade 1 spondylolisthesis (or retrolisthesis), and (3) thickening of the ligamentum flavum or scarring of the facet joint capsule. Success will be assessed by means of a composite endpoint that measures improvement in in patient reported outcomes and the absence of any major device related complications.

    at UC Irvine

  • Clinical Trial of Experimental LimiFlex for Treating Degenerative Spondylolisthesis With Spinal Stenosis (narrowing of the spine)

    open to eligible people ages 25-80

    The LimiFlex™ Clinical Trial is a prospective, concurrently controlled, multi-center study to evaluate the safety and effectiveness of decompression and stabilization with the Empirical Spine LimiFlex™ Paraspinous Tension Band compared to decompression and transforaminal lumbar interbody fusion (TLIF) with concomitant posterolateral fusion (PLF) for the treatment of lumbar degenerative spondylolisthesis (Grade I per Meyerding classification) with spinal stenosis. Clinical trial sites will enroll solely LimiFlex subjects or solely TLIF/PLF subjects.

    at UC Davis

  • MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study

    open to eligible people ages 18 years and up

    This prospective longitudinal study will compare incidence rates of Medicare beneficiary surgical and minimally invasive intervention post index procedure, as well as harms associated with the MILD procedure, at 24 months post-treatment with MILD, tested against a control group of similar patients that have had a comparable procedure.

    at UCLA UCSF

  • SLIP II Registry: Spinal Laminectomy Versus Instrumented Pedicle Screw Fusion

    open to eligible people ages 18 years and up

    The purpose of this registry is two fold. First, to determine the comparative effectiveness of decompression alone versus decompression with fusion for patients with degenerative grade I spondylolisthesis and symptomatic lumbar spinal stenosis. Primary analysis will focus on the patients' improvement from baseline patient-reported outcome questionnaires. The registry will also determine if an expert panel review of individual patient cases (degenerative grade I spondylolisthesis/stenosis) is associated with improved outcome and patient satisfaction. This study aims to prospectively collect comparative data for these patients treated with either decompression alone or decompression with fusion.

    at UCSF

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