Skip to main content

Malignant Hepatobiliary Neoplasm clinical trials at University of California Health

1 research study open to eligible people

Showing trials for
  • Testing the Combination of Two Anti-Cancer Drugs for Treating Advanced Solid Tumors with HER2 Expression

    “Volunteer for the DASH Trial and contribute to discoveries that may improve health care for you, your family, and your community!”

    open to eligible people ages 18 years and up

    The dose escalation phase of this trial identifies the best dose and safety of ceralasertib (AZD6738) when given in combination with trastuzumab deruxtecan (DS-8201a) in treating patients with solid tumors that have a change (mutation) in the HER2 gene or protein and have spread to other places in the body (advanced). The dose expansion phase (phase Ib) of this trial compares how colorectal and gastroesophageal cancers with HER2 mutation respond to treatment with a combination of ceralasertib and trastuzumab deruxtecan versus trastuzumab deruxtecan alone. Trastuzumab deruxtecan is a monoclonal antibody, called trastuzumab, linked to a chemotherapy drug, called deruxtecan. Trastuzumab attaches to HER2 positive cancer cells in a targeted way and delivers deruxtecan to kill them. Ceralasertib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

    at UC Davis

Our lead scientists for Malignant Hepatobiliary Neoplasm research studies include .

Last updated: