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Migraine clinical trials at UC Health
9 in progress, 6 open to eligible people

  • CHOCOlate MeLatonin for AdolescenT MigrainE

    open to eligible people ages 3-17

    Existing treatments for acute migraine are not effective for all children and adolescents, and can cause side effects. We propose a dose-finding study of melatonin for acute migraine treatment in children and adolescents to determine the best dose to bring forward in a future fully-powered efficacy trial.

    at UCSF

  • Melatonin for Adolescent Migraine Prevention Study

    open to eligible people ages 10-17

    This will be a randomized, multi-site double-blind placebo-controlled trial of melatonin (2 different dosing arms) vs. placebo for migraine prevention in adolescents. We intend to enroll approximately 210 participants over 15 months at two sites: UCLA and UCSF. The duration of participation for each participant will be 4 months.

    at UCLA UCSF

  • Non-invasive Vagus Nerve Stimulation for the Prevention of Migraines

    open to eligible people ages 18-75

    The purpose of the study is to investigate if the use of gammaCore Sapphire™ device reduces the number of migraines preventatively.

    at UCSF

  • Rizatriptan for Episodic Dizziness in Vestibular Migraine

    open to eligible people ages 18-65

    Suffering from dizzy spells and migraine headaches? Vestibular Migraine (VM), a newly recognized type of migraine that causes bouts of dizziness. University of California, Los Angeles (UCLA) and The Mayo Clinic is seeking people with VM to participate in a research study. The purpose of this study is to look at the natural history of VM and learn more about common symptoms. Investigators also want to learn the effects, both positive and negative, of the commonly used migraine drug, rizatriptan, when it is used for spells of dizziness in people with VM. Patients may be eligible to participate if: - Patients are between the ages of 18 & 65 - Patients have a history of vestibular migraine - Patients are able to maintain a vestibular symptom diary The study includes 3 visits with compensation. All participants must complete questionnaires on dizziness, headache symptoms, general health and well-being, mental health, and a questionnaire on patient's satisfaction with study medication.

    at UCLA

  • Sphenopalatine Ganglion Blocks RCT

    open to eligible people ages 18 years and up

    RCT of Sphenopalatine Ganglion (SPG) Blocks using anesthetics vs. placebo for migraine.

    at UCSF

  • Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments

    open to eligible females ages 18-50

    Vestibulodynia (VBD) is a complex chronic vulvar pain condition that impairs the psychological, physical, and sexual health of 1 in 6 reproductive aged women in the United States. Here, the investigators plan to conduct a randomized, double-blinded, placebo-controlled clinical trial to 1) compare the efficacy of peripheral (lidocaine/estradiol cream), centrally-targeted (nortriptyline), and combined treatments in alleviating pain and improving patient-reported outcomes and 2) determine cytokine and microRNA biomarkers that predict treatment response in women with distinct VBD subtypes. Positive findings from this study will readily translate to improved patient care, permitting the millions of women with VBD, their partners, and their clinicians to make more informed decisions about pain management.

    at UCLA

  • A Study of Lasmiditan (LY573144) Over Four Migraine Attacks

    Sorry, not currently recruiting here

    The reason for this study is to see how effective and safe the study drug known as lasmiditan is in the acute treatment of 4 migraine attacks with or without aura.

    at UCSD

  • Effectiveness of Onabotulinumtoxin A (Botox) in Pediatric Patients Experiencing Migraines: A Study in the Pediatric Pain Population

    Sorry, in progress, not accepting new patients

    The purpose of the research is to examine the outcomes of pediatric patients receiving Botulinum toxin type A (Botox ®) for the treatment of migraine. There is limited literature on the effectiveness of Botox ® in the treatment of chronic neurological pain in pediatric patients, specifically in the treatment of migraines.

    at UC Irvine

  • Study of Pediatric Migraine: The Pediatric Migraine Registry

    Sorry, in progress, not accepting new patients

    This is a multi-center registry that will prospectively collect regulatory compliant data from children and adolescents with migraine. This study will enroll approximately 200 participants from approximately 20 sites and will examine migraine symptoms, therapeutics used, and biomarkers associated with migraine.

    at UCSF

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