Multiple System Atrophy clinical trials at UC Health

• North American Prodromal Synucleinopathy Consortium

  open to eligible people ages 18 years and up

  This study will enroll participants with idiopathic rapid eye movement (REM) sleep behavior disorder (RBD), for the purpose of preparing for a clinical trial of neuroprotective treatments against synucleinopathies.

  at UCLA

• Trial of Parkinson's And Zoledronic Acid

  open to eligible people ages 60 years and up

  This home-based study is a randomized (1:1) placebo-controlled trial of a single infusion of zoledronic acid-5 mg (ZA) for the prevention of fractures in men and women aged 60 years and older with Parkinson's disease and parkinsonism with at least 2 years of follow-up. A total of 3500 participants will be enrolled and randomized in the United States. Participants, follow-up outcome assessors, and study investigators will be blinded to assigned study treatment. This trial is funded by the National Institute of Aging.

  at UC Davis UCSF

• GDNF Gene Therapy for Multiple System Atrophy

  Sorry, not yet accepting patients

  The objective of this randomized, double-blinded, placebo-controlled Phase 1 investigation is to evaluate the safety and potential clinical effect of AAV2-GDNF delivered to the putamen in subjects with either a possible or probable diagnosis of Multiple System Atrophy.

  at UC Irvine UCSD

• More Than a Movement Disorder: Applying Palliative Care to Parkinson's Disease

  Sorry, in progress, not accepting new patients

  This is a two-center (University of Colorado, University of California San Francisco) community-based comparative effectiveness study of outpatient palliative care for Parkinson's disease (PD) and related disorders (progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), multiple systems atrophy (MSA), Lewy Body Dementia (LBD). In September 2018, the study was amended to also include Alzheimer's disease (AD) and related disorders (Frontotemporal Dementia (FTD), Primary Progressive Aphasia (PPA), Vascular Dementia). It will utilize a randomized stepped-wedge design to compare patient and caregiver outcomes between usual care in the community versus usual care augmented by palliative training and telemedicine support to provide other resources (e.g. social work).

  at UCSF

• Study of BHV-3241 in Subjects With Multiple System Atrophy

  Sorry, in progress, not accepting new patients

  The purpose of this study is to compare the efficacy of BHV-3241 versus placebo in subjects with Multiple System Atrophy

  at UCLA UCSD UCSF

Last updated: January 27, 2021