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Opioid Use clinical trials at UC Health
6 in progress, 2 open to new patients

  • Improving Communication About Pain and Opioids

    open to eligible people ages 18 years and up

    The overall goal of this protocol is to pilot test a clinician training intervention that uses standardized patients (trained actors playing patient roles) as instructors who impart communication skills to primary care clinicians. This project will conduct a pilot clinical trial of the intervention developed by the primary investigator in order to evaluate intervention feasibility and generate data to plan a subsequent fully-powered, multisite trial. Primary care clinicians will be randomized to receive either the intervention or control; 48 patients (2 per clinician) will then be recorded during clinic visits with study clinicians and will provide data on post-visit perceptions and health outcomes. Study hypotheses are that visits with clinicians who receive the intervention (versus control) will be associated with more frequent use of targeted communication skills, lower probability of high-risk opioid prescribing, higher patient-reported agreement with treatment plan, and lower pain interference 2 months later.

    at UC Davis

  • Stimulant Oxytocin Study

    open to eligible people ages 18 years and up

    This study will investigate the effects of intranasal administration of oxytocin, a social neuropeptide, on reducing cocaine use, enhancing therapeutic engagement, and susceptibility to stress-induced relapse in Veterans with cocaine use disorder and enrolled in opioid replacement therapy (ORT) program for co-occurring opioid use disorder (OUD).

    at UCSF

  • Clinical Decision Support to Implement ED-initiated Buprenorphine for OUD

    Sorry, not yet accepting patients

    Emergency Departments (EDs) frequently care for individuals with Opioid Use Disorder (OUD). Buprenorphine (BUP) is an effective treatment option for patients with OUD that can safely be initiated in the ED. At present, BUP is rarely initiated as a part of routine ED care. Clinical decision support (CDS) represents a potential approach to accelerate adoption of this best practice into routine emergency care. The goal of this trial is to determine whether implementation of a user-centered clinical decision support (CDS) system can increase adoption of initiation of BUP into the routine emergency care of individuals with OUD.

    at UC Davis

  • Minimally Invasive Thoracic Surgery Intercostal Nerve Block Trial

    Sorry, not yet accepting patients

    The Minimally Invasive Thoracic Surgery Intercostal Nerve Block Trial is a single center, double-blind, randomized, active-comparator controlled clinical trial to assess the analgesic efficacy of intercostal nerve block by Liposomal Bupivacaine versus Standard Bupivacaine in subjects undergoing lung resection by robotic or video-assisted thoracoscopic surgery.

    at UCSF

  • Patient Decision Aid for Opioid Use Disorder

    Sorry, not yet accepting patients

    The aim of the study is to test the effectiveness of PtDA-MAT by conducting a stepped-wedge cluster-randomized trial in CA H&SS (stratified by rural vs. non-rural areas) for adults with OUD. Patient outcomes will be tracked by (1) personal assessments (baseline, 3 months, and 6 months): drug use, overdose, healthcare utilization, and (2) clinical and administrative records (over an average of 24 months): drug treatment status and retention, physical and mental health diagnoses, arrest, incarceration, controlled substance use, and mortality. Multilevel models will be applied to test the intervention effects, controlling for possible temporal trends.

    at UCLA

  • Pilot Test of Patient Decision Aid for Opioid Use Disorder

    Sorry, not yet accepting patients

    The aims of the current study phase (R21) are: Aim 1. Develop a patient decision aid (PtDA-MAT) by incorporating best available scientific evidence on MAT as well as feedback from patients and clinical providers related to clinical priorities, perceived utility, and acceptability; Aim 2. Conduct pilot testing of the PtDA-MAT in an iterative process guided by an expert panel and involving key stakeholders (e.g., patients, physicians, policymakers) and field-testing.

    at UCLA

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