Opioid Use clinical trials at University of California Health
25 in progress, 14 open to eligible people
"Bupe by the Book": A Tele-Buprenorphine Clinical Trial in Public Libraries With Unstably Housed Persons With Opioid Use Disorder
open to eligible people ages 18 years and up
Public libraries nationwide are facing an on-premise opioid overdose crisis. Many persons with opioid use disorder (OUD) remained unhoused and profoundly hard to reach. This study innovatively develops and tests a telemedicine intervention delivered …
at UCSD
Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder
open to eligible people ages 18 years and up
VA-BRAVE will determine whether a 28-day long-acting injectable sub-cutaneous (in the belly area) formulation of buprenorphine at a target dose of 300mg is superior in retaining Veterans in opioid treatment and in sustaining opioid abstinence…
at UCSF
Gabapentin to Reduce Opioid Use Postoperatively (GROUP) in Children
open to eligible people ages up to 17 years
The primary objective of this study is to determine if the peri and post operative use of gabapentin in children reduces the need for narcotics after thoracic surgery. We hypothesize that patients who are given gabapentin will need fewer morphine…
at UC Davis
ENDOblock: Bilateral Superficial Cervical Blocks With Local Wound Infiltration in Thyroid Surgery
open to eligible people ages 18-99
This is a single center, prospective, double-blinded randomized controlled trial comparing the efficacy of bilateral superficial cervical plexus blocks (BSCPB) with local wound infiltration vs placebo with local wound infiltration in reducing…
at UC Davis
Improving Equitable Access to Naloxone to Prevent Opioid Overdose Deaths Within Syringe Service Programs (SAIA-Naloxone)
open to eligible people ages 18 years and up
The goal of this clinical trial is to compare the effectiveness of a multi-faceted implementation strategy, the Systems Analysis and Improvement Approach for Naloxone (SAIA-N), in syringe service programs (SSPs). The main questions it aims to answer …
at UCSD
Managing Opioid Related Sleep Apnea With Acetazolamide
open to eligible people ages 18 years and up
Patients with chronic pain who use opioids appear to be at increased risk for breathing issues during sleep, termed sleep disordered breathing (SDB). Treatment of SDB often consists of use of a device during sleep that provides continuous positive…
at UCSD
Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.
open to eligible people ages 18-99
The purpose of this clinical trial is to compare the effectiveness of office-based methadone with pharmacy administration and/or dispensing to office-based buprenorphine for the treatment of opioid use disorder. This study will also examine factors…
at UCSF
Patient Decision Aid for Opioid Use Disorder
open to eligible people ages 18 years and up
The aim of the study is to test the effectiveness of the Patient Decision Aid for Opioid Use Disorder (PtDA-MAT) by conducting a stepped-wedge cluster-randomized trial in CA H&SS (stratified by rural vs. non-rural areas) for adults with OUD. Patient …
at UCLA
Postoperative Opt-In Narcotics Treatment in Breast
open to eligible people ages 18 years and up
In a recent study, researchers let patients choose what medications to go home with after endocrine surgery. This has not been done in outpatient breast surgery, though several institutions have moved towards avoiding opioids altogether after breast …
at UCLA
Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age
open to eligible people ages 40-60
This study will establish the relationship between magnitude of opioid exposure and a pupillary measure referred to as PUAL (pupillary unrest in ambient light), in subjects aged 40-60. Previous investigation demonstrated that loss of PUAL was a…
at UCSF
Leveraging Artificial Intelligence and Multi-Omics Data to Predict Opioid Addiction
open to eligible people ages 18 years and up
The primary goal of this proposal is to validate a novel genomic and microbiome predictive model that may be used to assess a person's risk of developing opioid use disorder (OUD). The following will be tested: (1) MODUS (Measuring risk for Opioid…
at UCSD
Predicting Chronic Opioid Use Following Lower Extremity Joint Arthroplasty
open to eligible people ages 18 years and up
Personalized medicine is a concept in which medical care is individualized to a patient based on their unique characteristics, including comorbidities, demographics, genetics, and microbiome. After major surgery, some patients are at increased risk…
at UCSD
Predicting Chronic Pain Following Breast Surgery
open to eligible people ages 18 years and up
Breast surgery, which includes mastectomy, breast reconstructive surgery, or lumpectomies with sentinel node biopsies, may lead to the development of chronic pain and long-term opioid use. In the era of an opioid crisis, it is important to…
at UCSD
Association of Microbiome Patterns With Chronic Opioid Use
open to eligible people ages 18 years and up
The United States is in the midst of an opioid epidemic, with the number of opioid-related deaths having risen six-fold since 1999. Chronic pain imposes a tremendous economic burden of up to US$635 billion per year in terms of direct costs (such as…
at UCSD
Test Whether BI 1356225 Improves Impulsive Behavior in Men With Opioid Use Disorder Who Are Taking Buprenorphine
Sorry, not currently recruiting here
This study is open to men between 18 and 65 years of age with opioid use disorder. Opioid use disorder is also called opioid addiction or opioid dependence. People can join the study if they currently take a medicine called buprenorphine. People…
at UCLA
Adapting the HOPE Online Support Intervention to Increase Uptake of Medications for Opioid Use Disorder
Sorry, in progress, not accepting new patients
In a randomized controlled trial, with 3, 6-month and 1-year follow-up, this application aims to explore whether and how the HOPE intervention can be adapted to increase MOUD uptake among OUD patients, assess the effectiveness of using HOPE to…
at UC Irvine
Patient Preference for Intraoperative Opioid Use on Early Postoperative Quality of Recovery
Sorry, not yet accepting patients
Substituting the administration of opioids with a combination of alternative analgesics, known as opioid-free anesthesia (OFA), is gaining in popularity today and is typically administered as part of a larger multimodal strategy. However, OFA…
at UCLA
CBT-based mHealth Intervention Targeting MOUD Retention, Adherence, and Opioid Use
Sorry, accepting new patients by invitation only
The focus of this study is to examine the effectiveness of imFREE relative to mHealth ED in facilitating treatment retention and adherence and reducing opioid use among adults with OUD initiating BUP treatment. There are two specific aims: (1) to…
at UCLA UCSD
High Dose Buprenorphine (BUP) Induction in the Emergency Department (ED)
Sorry, not currently recruiting here
This project, involving two distinct clinical trials, tests whether induction to a higher than currently recommended buprenorphine (BUP) induction dose is safe and can improve the proportion of patients who engage in comprehensive addiction services …
at UCLA
Improving Postamputation Functioning by Decreasing Phantom Pain With Perioperative Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study
Sorry, accepting new patients by invitation only
When a limb is amputated, pain perceived in the part of the body that no longer exists often develops, called "phantom limb" pain. The exact reason that phantom limb pain occurs is unclear, but when a nerve is cut-as happens with an…
at UCSD
Naloxone for Opioid Associated Out of Hospital Cardiac Arrest
Sorry, not yet accepting patients
The investigator's long-term goal is to conduct Naloxone for Opioid Associated out of Hospital Cardiac Arrest (NOPACA), a randomized, double blind, controlled trial to determine the efficacy of naloxone vs. placebo in Opioid Associated out of…
at UCSF
Naltrexone for Overdose Prevention
Sorry, not yet accepting patients
The goal of this clinical trial is to see if an injectable medicine called naltrexone can prevent fentanyl overdose deaths in people who use other drugs (cocaine, methamphetamine). The main questions it aims to answer are: What are the challenges…
at UCSF
Pain and Opioids: Integrated Treatment In Veterans
Sorry, in progress, not accepting new patients
This trial will recruit veterans with chronic pain (N = 160) who are prescribed buprenorphine for the treatment of opioid use disorder (OUD). We seek to: (1) examine the efficacy of an integrated treatment to reduce pain interference (Acceptance and …
at UCSF
TACUNA (Traditions and Connections for Urban Native Americans)
Sorry, in progress, not accepting new patients
This study responds to Request For Application-DA-19-035, HEAL (Helping End Addiction Long Term) initiative: Preventing OUD in Older Adolescents and Young Adults (ages 16-30) by developing and implementing a culturally centered intervention to…
at UCLA
Clinical Decision Support to Provide Social Risk-Informed Care for Opioid Use Disorder in the Emergency Department
Sorry, not yet accepting patients
The overarching goal of this proposal is to integrate patient social risk information into an existing electronic health record (EHR)-based clinical decision support (CDS) tool (CDSv1) to facilitate emergency department (ED)-initiated, social…
at UCSF
Our lead scientists for Opioid Use research studies include Lianne Urada Andy Tompkins, MD Ayesha Appa Sean D Young, PhD Larissa Mooney, M.D. Melanie F Molina, MD, MAS Brian M Ilfeld, MD, MS Ralph Wang, MD, MAS Jeremy Orr, MD Michael Campbell, MD Rodney A Gabriel, MD Gary Raff, MD James Wu, MD Paula Lum, MD Alexandre P. Joosten, MD, PhD.
Last updated: