Plexiform Neurofibroma clinical trials at UC Health
2 in progress, 1 open to eligible people

• Phase II Study of Binimetinib in Children and Adults With NF1 Plexiform Neurofibromas

  open to eligible people ages 1 year and up

  This is a phase II open label study that will evaluate children ≥ 1 year of age and adults with neurofibromatosis type 1 (NF1) and plexiform neurofibromas treated with the MEK inhibitor, binimetinib. The primary objective is to determine if there is an adequate level of disease responsiveness to binimetinib in children and adults with NF1 and inoperable plexiform neurofibromas. The objective response to binimetinib is defined as ≥ 20% decrease in tumor volume reduction by 12 courses.

  at UCLA UCSD UCSF

• MEK Inhibitor Mirdametinib (PD-0325901) in Patients With Neurofibromatosis Type 1 Associated Plexiform Neurofibromas

  Sorry, not currently recruiting here

  This study evaluates PD-0325901 in the treatment of symptomatic inoperable neurofibromatosis type-1 (NF1)-associated plexiform neurofibromas (PNs). All participants will receive PD-0325901.

  at UCLA

Last updated: January 7, 2020