Pregnancy clinical trials at University of California Health
29 in progress, 13 open to eligible people
Anticoagulation Profile in Pregnant Women Treated with Three Times a Day of Low Molecular Weight Heparin (LMWH)
open to eligible females ages 18 years and up
Pregnancy is associated with a increased risk of developing blood clots. There is nearly a 5 times greater risk of developing a blood clot in pregnancy. Lovenox is a medication that helps to prevent the body from developing clots. It is safe to use…
at UC Irvine
DETERMINE: Detemir vs NPH
open to eligible people ages 18 years and up
The purpose of the study is to compare rates of neonatal hypoglycemia with maternal NPH vs determir use.
at UCLA
Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL
open to eligible females ages 14-35
The overall goal of this large, pragmatic, comparative effectiveness trial is to test the hypothesis that among at-risk individuals, 162 mg/day aspirin is superior to 81 mg/day in preventing Hypertensive disorders of pregnancy (HDP), and that there…
at UCSF
Engaging Mothers & Babies; Reimagining Antenatal Care for Everyone (EMBRACE) Study
open to eligible females
This is a randomized comparative effectiveness study of two forms of enhanced prenatal care among 657 Medi-Cal eligible pregnant individuals in Fresno, California. The goal is to see whether group prenatal care with wrap around services versus…
at UCSF
Resources, Inspiration, Support and Empowerment (RISE) for Black Pregnant Women
open to eligible females ages 18-65
Perinatal Mood and Anxiety Disorders (PMADs) encompass a range of mental health disorders that occur during pregnancy and up to one year postpartum. Approximately 13% of women experience PMADs. This rate doubles for those with adverse perinatal…
at UCLA
Periviable GOALS Decision Support Tool
open to eligible people ages 18 years and up
The Periviable GOALS (Getting Optimal Alignment around Life Support) decision support tool (DST) is meant to facilitate informed shared decision-making regarding neonatal resuscitation for families facing the threat of a periviable delivery…
at UCSD UCSF
Commercial or Open Source Closed Loop Impact on Pregnancy Study
open to eligible females ages 18 years and up
The goal of this observational study is to better understand what happens when pregnant people with type 1 diabetes (T1D) use automated insulin delivery (AID) systems. The main questions this study aims to answer are: - What are the maternal and…
at UCSF
Kesimpta (Ofatumumab) Pregnancy Registry
open to eligible people ages 18-100
The Kesimpta Pregnancy Registry is an observational, exposure cohort designed study to examine pregnancy and infant outcomes in women and infants who are exposed to Kesimpta (ofatumumab) during pregnancy to treat MS.
at UCSD
Monitoring Pregnancy and Infant Outcomes Following Tralokinumab Exposure During Pregnancy in the US and Canada - PROTECT
open to eligible females
The goal of this observational study is to learn about exposure to tralokinumab during pregnancy, as well as atopic dermatitis (AD) during pregnancy. The main question the study aims to answer is whether pregnant people who have been exposed to…
at UCSD
Properties of Antiretroviral and Anti-Tuberculosis Drugs During Pregnancy and Postpartum
open to eligible females
The purpose of this study is to evaluate the pharmacokinetic (PK) properties of antiretroviral (ARV) and anti-tuberculosis (TB) drugs administered during pregnancy and postpartum.
at UCLA UCSD
Specimen Collection from Pregnant Women At Increased Risk for Fetal Aneuploidy
open to eligible females ages 18 years and up
The specimen collection is designed for the purpose of the development of a noninvasive prenatal test for T21.
at UCSD
Stelara and Tremfya Pregnancy Exposure Registry OTIS Autoimmune Diseases in Pregnancy Project
open to eligible females
The purpose of the OTIS Autoimmune Diseases in Pregnancy Study is to monitor planned and unplanned pregnancies exposed to certain medications, to evaluate the possible teratogenic effect of these medications and to follow live born infants for one…
at UCSD
UCLA Perinatal Biospecimen Repository
open to all eligible people
The purpose of this investigator-initiated prospective observational cohort study is to establish the new UCLA Perinatal Biospecimen Repository (Perinatal Repository) for collection, storage, and distribution of the human data and biospecimens of…
at UCLA
B Cell Levels In Infants Potentially Exposed To Ocrelizumab During Pregnancy
Sorry, in progress, not accepting new patients
This study will evaluate the potential placental transfer of ocrelizumab in women with clinically isolated syndrome (CIS) or multiple sclerosis (MS) [in line with the locally approved indications] whose last dose of ocrelizumab was administered any…
at UCSF
Automated Insulin for Management of Intrapartum Glycemia
Sorry, not yet accepting patients
The goal of this clinical trial is learn if automated insulin delivery (AID) systems can be used for glucose management during labor/delivery for pregnant people with type 1 diabetes (T1D). The main questions this study aims to answer are - What are …
at UCSF
CGM for Management of Type 2 Diabetes in Pregnancy
Sorry, not yet accepting patients
The goal of this clinical trial is to learn if continuous glucose monitoring works better than self-monitoring of blood glucose (fingersticks) to treat type 2 diabetes in pregnancy. It will also learn about all risk factors (biologic, personal,…
at UCSD
Conscious Pregnancy: Supporting Maternal Cardiometabolic Health with Mindfulness
Sorry, not yet accepting patients
A pilot randomized control trial (RCT) to examine the efficacy of a culturally tailored mindfulness intervention upon fasting cardiometabolic factors (including markers of glycemic control) and inflammatory gene expression in n=60 (n=30…
at UC Irvine
CREATE - Cabotegravir & Rilpivirine Antiretroviral Therapy in Pregnancy
Sorry, not yet accepting patients
This is a Phase I/II, multicenter, open-label, non-randomized study with four groups to characterize the pharmacokinetics and safety of Cabotegravir (CAB) and Rilpivirine (RPV) long-acting injectable (LA) during pregnancy and postpartum among people …
at UCSD
DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes
Sorry, not currently recruiting here
This is a non-inferiority patient-centered and pragmatic comparative-effectiveness pregnancy randomized controlled trial (RCT) with postpartum maternal and child follow-up through 2 years of 1,572 individuals with gestational diabetes mellitus (GDM) …
at UCSF
Developing and Testing the Jenga Dada Intervention in Kenya
Sorry, not yet accepting patients
This study aims to work with women's economic empowerment groups within the community to address reproductive coercion and intimate partner violence and promote economic self-sufficiency among women (aged 15+ years). Based on the investigators'…
at UCSD
Tolerability of VeraCept IUD
Sorry, in progress, not accepting new patients
To assess the contraceptive efficacy (prevention of pregnancy) of VeraCept
at UC Davis
Tolerability of LevoCept
Sorry, not yet accepting patients
To assess the contraceptive efficacy (prevention of pregnancy) of LevoCept
at UC Davis
Goals for Reaching Optimal Wellness: GROWell
“We're looking for healthy pregnant people to participate in a mobile health program”
Sorry, in progress, not accepting new patients
Despite the negative consequences to maternal-child health from women gaining too much weight during pregnancy, up to 62% of overweight and obese women gain more pregnancy weight than is recommended. This project will establish the efficacy of Goals …
at UC Davis
Natural Versus Programmed Frozen Embryo Transfer (NatPro)
Sorry, in progress, not accepting new patients
NatPro is a two-arm, parallel-group, multi-center, randomized trial in which women undergoing frozen embryo transfer (FET) will be randomized to receive either a modified natural cycle (corpus luteum present) or a programmed cycle (corpus luteum…
at UCSF
Rigorous Evaluation of Yes and Know, a Fully Virtual Sexual Health and Well-Being Intervention for Youth
Sorry, not yet accepting patients
This study is a 2-arm cluster randomized controlled trial with approximately 1,200 youth aged 14-19 years to assess the effectiveness of Yes and Know, a sexual health education program. To be eligible, participants must be 14-19 years old and…
at UCSF
Pregnancy In the CoRonavirus (COVID-19) pandEmic
Sorry, in progress, not accepting new patients
Prospective nationwide cohort study of pregnant women enrolled early in gestation and followed for Covid-19 exposure and infection, with follow up of obstetrical outcomes and infant development through the first year of life.
at UCSF
Attitudes and Decision-making After Pregnancy Testing Study
Sorry, in progress, not accepting new patients
The ADAPT Study is a longitudinal observational cohort study examining women's pregnancy preferences, pregnancy decision-making processes, and the effects of less preferred (commonly called "unintended") pregnancy on women's lives. This study will…
at UCSF
MIRACLE of LIFE Study
Sorry, in progress, not accepting new patients
The goal of this observational study is to develop and validate cell-free RNA-based biomarkers for predicting a variety of adverse pregnancy outcomes in a pregnant person population. The main question it aims to answer are: 1. Can cell-free…
at UCSD
Pregnancy in Women with Cystic Fibrosis
Sorry, in progress, not accepting new patients
In this study, the investigators aim to evaluate changes in lung function in women with cystic fibrosis (CF) during pregnancy and for 2 years after pregnancy based on exposure to highly effective cystic fibrosis transmembrane conductance regulator…
at UCSD
Our lead scientists for Pregnancy research studies include Afshan Hameed Heather Huddleston, MD Corinne Rocca, PhD Yalda Afshar, MD, PhD Mitchell Creinin, MD Christina Chambers Jay G Silverman, PhD Lauren E Gyllenhammer, PhD Miriam Kuppermann, PhD, MPH Christina S. Han, MD Nasim Sobhani, MD.
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