Primary Biliary Cholangitis clinical trials at University of California Health

10 in progress, 6 open to eligible people

Showing trials for

  • A Study Evaluating an Investigational Medicine for Treating PBC Itch (The GLISTEN Trial)

    “Volunteering for the GLISTEN trial could bring much-needed medical progress in PBC itch!”

    open to eligible people ages 18-80

    This is a 2-part study in PBC participants with cholestatic pruritus and will evaluate the efficacy, safety and impact on health-related quality of life of linerixibat compared with placebo.

    at UCSF

  • A Study of Seladelpar in Patients with Primary Biliary Cholangitis (PBC) and Abnormal Liver Function

    “Volunteer for research and contribute to discoveries that may improve health care for you, your family, and your community!”

    open to eligible people ages 18-80

    The Effect of Hepatic Impairment on The Pharmacokinetics of Seladelpar: An Open-Label Study Following Oral Dosing of Seladelpar to Subjects with Primary Biliary Cholangitis (PBC) and Hepatic Impairment (HI)

    at UC Davis

  • A Trial of Setanaxib in Patients With Primary Biliary Cholangitis (PBC) and Liver Stiffness

    open to eligible people ages 18 years and up

    The primary objective of this study is to evaluate the effect of setanaxib on biochemical response at Week 52 in participants with primary biliary cholangitis (PBC) and with elevated liver stiffness and intolerance or inadequate response to ursodeoxycholic acid (UDCA).

    at UC Davis

  • Saroglitazar Magnesium for Treatment of Primary Biliary Cholangitis

    open to eligible people ages 18-75

    Saroglitazar Magnesium 1 mg and 2 mg tablets for treatment of subjects with Primary Biliary Cholangitis (PBC)

    at UC Davis

  • Seladelpar in Subjects With Primary Biliary Cholangitis (PBC)

    open to eligible people ages 18-75

    An Open Label Long-Term Study to Evaluate the Safety and Tolerability of Seladelpar in Subjects with Primary Biliary Cholangitis (PBC)

    at UC Davis

  • Study to Evaluate a Potential New Treatment in Primary Biliary Cholangitis

    “Volunteer for research and contribute to discoveries that may improve health care for you, your family, and your community!”

    open to eligible people ages 18-75

    This study is a Phase 2a First-in-Human (FIH) clinical trial to assess the safety, tolerability, pharmacodynamics (PD), and efficacy of multiple ascending doses of CNP-104. The study consists of a 120 day primary study followed by a 20 month long-term safety and durability of response follow-up period.

    at UC Davis

  • A Study of Investigational Seladelpar in Primary Biliary Cholangitis (PBC)

    “Volunteer for research and contribute to discoveries that may improve health care for you, your family, and your community!”

    Sorry, in progress, not accepting new patients

    To evaluate the treatment effect of seladelpar on composite biochemical improvement in cholestasis markers based on ALP and total bilirubin and to evaluate the safety of seladelpar over 12 months of treatment compared to placebo

    at UC Davis

  • If you’re living with Primary Biliary Cholangitis, learn about our study of a novel combination therapy

    “Primary Biliary Cholangitis may be rare. But we’re working together.”

    Sorry, in progress, not accepting new patients

    Study to determine the effect of the investigational drug bezafibrate (BZF) alone and in combination with the investigational drug obeticholic acid (OCA) in participants with Primary Biliary Cholangitis (PBC).

    at UC Davis

  • Study of Elafibranor in Patients With Primary Biliary Cholangitis (PBC)

    Sorry, in progress, not accepting new patients

    The main objective of the study is to evaluate the effect of daily oral administration of 80mg elafibranor on cholestasis (impairment of bile formation and/or bile accumulation) in patients with PBC and inadequate response or intolerance to Ursodeoxycholic Acid (UCDA). In the DB period, patients will be randomized in a 2:1 ratio to receive Elafibranor 80 mg or placebo, once daily.

    at UC Davis

  • A 5-year Longitudinal Observational Study of Patients With Primary Biliary Cholangitis

    Sorry, in progress, not accepting new patients

    This is a 5-year, longitudinal, observational study of patients with PBC designed to specifically address important clinical questions that remain incompletely answered from registration trials. In addition to the study database, a bio specimen repository will also be included so that translational studies of genomics and biomarkers of response may be performed.

    at UC Davis

Our lead scientists for Primary Biliary Cholangitis research studies include .

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