Retinitis Pigmentosa clinical trials at University of California Health

13 in progress, 5 open to eligible people

Showing trials for

  • Oral N-acetylcysteine for Retinitis Pigmentosa

    open to eligible people ages 18-65

    Retinitis pigmentosa (RP) is an inherited retinal degeneration caused by one of several mistakes in the genetic code. Such mistakes are called mutations. The mutations cause degeneration of rod photoreceptors which are responsible for vision in dim…

    at UC Davis UCSF

  • Single, Intravitreal Injection of 8.8M jCell (Famzeretcel) in Retinitis Pigmentosa (RP)

    open to eligible people ages 18-60

    This study evaluates the safety of a single injection of jCell (famzeretcel) comprising 8.8 million (8.8M) retinal progenitor cells over a six-month study period in a cohort of adult subjects with RP. Additionally, changes in visual function will be …

    at UC Irvine UCSD

  • RTx-015 Injection in Retinitis Pigmentosa or Choroideremia Patients (ENVISION)

    open to eligible people ages 18 years and up

    A Phase 1, open-label, non-randomized, dose-escalation study, where approximately 15 eligible patients with retinitis pigmentosa or choroideremia will be enrolled sequentially in up to 3 dose cohorts of RTx-015. Enrolled patients will receive a…

    at UC Irvine

  • Retinal Imaging in Patients With Inherited Retinal Degenerations

    open to eligible people ages 13 years and up

    The purpose of this study is to determine whether the structure and function of the human retina can be studied with high resolution in patients with inherited retinal degenerations using the Adaptive Optics Scanning Laser Ophthalmoscope (AOSLO).

    at UCSF

  • Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants

    open to eligible people ages 4 years and up

    This is an international, multicenter study with two components: Registry - A standardized genetic screening and a prospective, standardized, cross-sectional clinical data collection - Enrollment is open to all genes on the RD Rare Gene List Natural …

    at UCSF

  • OCU400 Gene Therapy for the Treatment Of Retinitis Pigmentosa

    Sorry, not currently recruiting here

    This is a Phase 3 study to Assess the Efficacy, Safety and Tolerability of OCU400 in patients with retinitis pigmentosa (RP) associated with RHO mutations and patients with any other RP associated mutation with a clinical phenotype of RP. This is a…

    at UCSD

  • Autologous Intravitreal Bone-marrow CD34+ Stem Cells for Retinopathy

    “We hope to learn more about the safety and feasibility of using your own (autologous) stem cells extracted from your bone marrow.”

    Sorry, in progress, not accepting new patients

    This pilot study is to determine whether it would be safe and feasible to inject CD34+ stem cells from bone marrow into the eye as treatment for patients who are irreversibly blind from various retinal conditions.

    at UC Davis

  • Long-term Safety and Efficacy Follow-up of BIIB111 for the Treatment of Choroideremia and BIIB112 for the Treatment of X-Linked Retinitis Pigmentosa

    Sorry, accepting new patients by invitation only

    The objective of the study is to evaluate the long-term safety and efficacy of a sub-retinal injection of BIIB111 in participants with Choroideremia (CHM) who have been previously treated with BIIB111 and who have exited an antecedent study; these…

    at UCLA

  • OCU400 for Retinitis Pigmentosa and Leber Congenital Amaurosis

    Sorry, in progress, not accepting new patients

    This is a Phase 1/2 Study to Assess the Safety and Efficacy of OCU400 in patients with retinitis pigmentosa associated with NR2E3 and RHO mutations and in patients with LCA due to mutation(s) in CEP290 gene (OCU400-101). To document prospective eye…

    at UCSD

  • PRPF31 Mutation-Associated Retinal Dystrophy

    Sorry, in progress, not accepting new patients

    The purpose of this study is to characterize the natural history through temporal systemic evaluation of subjects identified with PRPF31 mutation-associated retinal dystrophy, also called retinitis pigmentosa type 11, or RP11. Assessments will be…

    at UCSF

  • Rate of Progression in EYS Related Retinal Degeneration

    Sorry, in progress, not accepting new patients

    The overall goal of this project funded by the Foundation Fighting Blindness is to characterize the natural history of disease progression in patients with EYS mutations in order to accelerate the development of outcome measures for clinical trials.

    at UCSF

  • Rate of Progression in USH2A-related Retinal Degeneration

    Sorry, in progress, not accepting new patients

    The overall goal of this project funded by the Foundation Fighting Blindness is to characterize the natural history of disease progression in patients with USH2A related retinal degeneration associated with congenital hearing loss (Usher syndrome…

    at UCSF

  • Rate of Progression of PCDH15-Related Retinal Degeneration in Usher Syndrome 1F

    Sorry, in progress, not accepting new patients

    The overall goal of this project, co-funded by the Foundation Fighting Blindness and the USHER 1F Collaborative is to characterize the natural history of disease progression in patients with PCDH15 mutations in order to accelerate the development of …

    at UCSF

Our lead scientists for Retinitis Pigmentosa research studies include .

Last updated: