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Spinal Cord Injury clinical trials at UC Health
7 in progress, 6 open to eligible people

  • A Study of the Experimental Neuro-Spinal Scaffold™ Device for Complete Thoracic AIS A Spinal Cord Injury

    open to eligible people ages 16-70

    This is a randomized, controlled, single-blind, multicenter, two Arm (Treatment or "Scaffold" Arm; Standard of Care or "Comparator" Arm) of a Neuro-Spinal Scaffold to evaluate whether the Scaffold is safe and demonstrates probable benefit for the treatment of complete T2-T12 spinal cord injury as compared to standard of care open spine surgery.

    at UC Davis

  • Deep Brain Stimulation (DBS) for Chronic Neuropathic Pain

    open to eligible people ages 21 years and up

    This study evaluates invasive deep brain stimulation (DBS) in the treatment of three types of chronic neuropathic pain, i) Post Stroke pain syndrome ii) Phantom Limb pain and iii) Spinal Cord Injury Pain. Participants will be implanted with recording / stimulation electrodes in pain-related circuits of the brain. Relief of pain symptoms with stimulation will be studied in both groups. It is hypothesized that neural signals will correlate with pain states and that DBS can disrupt these pain states in both groups, perhaps with differences in underlying neural mechanisms for pain relief.

    at UCSF

  • ECoG BMI for Motor and Speech Control

    open to eligible people ages 21 years and up

    Test the feasibility of using electrocorticography (ECoG) signals to control complex devices for motor and speech control in adults severely affected by neurological disorders.

    at UCSF

  • Safety Study of Human Spinal Cord-derived Neural Stem Cell Transplantation for the Treatment of Chronic SCI

    open to eligible people ages 18-65

    This is a safety study of human spinal cord-derived neural stem cell (HSSC) transplantation for the treatment of chronic spinal cord injury.

    at UCSD

  • Telepsychology in Spinal Cord Injury

    open to eligible people ages 18 years and up

    This study will determine the effectiveness of tele-psychology in treating persons with spinal cord injury (SCI) with depressed mood in the early period post-rehabilitation discharge. Depression among individuals with SCI is the most common psychological condition following an injury; 22% of civilians with SCI and 28% of veterans with SCI experience depression after injury, which is higher than the able-bodied population (Williams 2015; Ullrich 2014). Individuals with SCI face many barriers in receiving psychotherapy, such as lack of accessible transportation, unfamiliarity with community resources, or stigma associated with seeking treatment for depression, which this project aims to address. Cognitive behavior therapy (CBT), which helps people develop different ways of thinking and behaving to reduce their psychological distress, will be provided via iPad FaceTime by a psychologist with expertise in working with persons with SCI. The objectives of the proposed project are to reduce depressive symptoms, decrease associated symptoms of anxiety, and to improve satisfaction with life with CBT provided via tele-psychology. The secondary objective is to show intermediate efficacy of tele-psychology in persons with SCI with depressed mood.

    at UCSF

  • The Canadian Multicentre CSF Monitoring and Biomarker Study

    open to eligible people ages 17 years and up

    The purpose of this study is to: 1. Measure the pressure in the spinal fluid surrounding the spinal cord to find out how well the spinal cord is being supplied with blood. 2. Determine how drugs called "vasopressors", which are used to control blood pressure following SCI (spinal cord injury), influence spinal fluid pressure. 3. Characterize the severity of an SCI using the levels of specific proteins found within the spinal fluid. 4. Predict how much neurologic recovery may be regained using the levels of specific proteins within your spinal fluid. 5. Identify proteins within the spinal fluid that will help us learn more about what is happening after SCI and assist us in developing new treatments for SCI.

    at UCSF

  • The INSPIRE Study: Probable Benefit of the Neuro-spinal Scaffold for Treatment of AIS A Thoracic Acute Spinal Cord Injury

    Sorry, in progress, not accepting new patients

    This is an open-label, non-randomized, single-arm, multicenter study to evaluate safety and probable benefit of the Neuro-Spinal Scaffold in treating complete T2-T12 spinal cord injury. This is a Humanitarian Device Exemption (HDE) Probable Benefit Study in support of future studies and an HDE application with subsequent approval.

    at UC Davis

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