Spinal Cord Injury clinical trials at University of California Health
19 in progress, 11 open to eligible people
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons with Tetraplegia
““Turn thoughts into action” for people living with paralysis”
open to eligible people ages 18-80
The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility) of the ability of people with tetraplegia to control a computer cursor and other assistive devices with their thoughts.
at UC Davis
Canadian-American Spinal Cord Perfusion Pressure and Biomarker Study
open to eligible people ages 17 years and up
This multicenter study will enroll 100 patients with acute traumatic cervical and thoracic SCI who have a lumbar intrathecal catheter inserted within 24 hours of their injury. The lumbar intrathecal catheter will be inserted pre-operatively for the…
at UCSF
Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain
open to eligible people ages 22-80
Chronic pain affects 1 in 4 US adults, and many cases are resistant to almost any treatment. Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but traditional approaches target…
at UCSF
ECoG BMI for Motor and Speech Control
open to eligible people ages 21 years and up
Test the feasibility of using electrocorticography (ECoG) signals to control complex devices for motor and speech control in adults severely affected by neurological disorders.
at UCSF
BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Speech-02)
open to eligible people ages 18-80
The goal of this study is to improve our understanding of speech production, and to translate this into medical devices called intracortical brain-computer interfaces (iBCIs) that will enable people who have lost the ability to speak fluently to…
at UC Davis
Improving Bladder Function in SCI by Neuromodulation
open to eligible males ages 18-45
This trial will investigate the safety and utility of spinal cord neuromodulation to improve urinary bladder function in the context of spinal cord injury.
at UCLA
Neuromodulation to Improve Respiratory Function in Cervical Spinal Cord Injury
open to eligible people ages 18-75
This is a phase 1 study of safety and feasibility of cervical spinal cord stimulator implantation in cervical SCI subjects who are ventilator dependent. The Investigators will be focusing on the safety and feasibility of this approach. Participants…
at UCLA
Telenutrition for Individuals With SCI
open to eligible people ages 20 years and up
This study will provide nutrition counseling via FaceTime on an iPad to persons with traumatic spinal cord injury (SCI) who are overweight or obese and are at least one-year post-injury. Nutrition counseling may help participants to develop eating…
at UCSF
Telerehabilitation Early After CNS Injury
open to eligible people ages 18 years and up
The goal of this clinical trial is to assess the safety and feasibility of providing extra doses of rehabilitation therapy for persons with a recent stroke, traumatic brain injury (TBI) and/or spinal cord injury (SCI). The therapy treatment targets…
at UCLA
Transcranial Magnetic Stimulation for Chronic Neuropathic Pain
open to eligible people ages 18-80
Chronic neuropathic pain is defined as pain caused by a lesion or disease of the somatosensory nervous system. It is highly prevalent, debilitating, and challenging to treat. Current available treatments have low efficacy, high side effect burden,…
at UCSF
Incomplete Cervical SCI Without Instability
open to eligible people ages 18-80
A multicenter, international, prospective, observational case series patient cohort with incomplete cervical SCI without instability will be enrolled to obtain information and data that could inform the feasibility of administering a set of…
at UCSF
Intravenous (IV) Administration Of Elezanumab To Assess Change In Upper Extremity Motor Score (UEMS) In Adult Participants With Acute Traumatic Cervical Spinal Cord Injury (SCI)
“Volunteer for research and contribute to discoveries that may improve health care for you, your family, and your community!”
Sorry, in progress, not accepting new patients
Acute Spinal Cord Injury (SCI) is a rare injury that leads to permanent neuromotor impairment and sudden disability. Approximately 25,000 people experience cervical SCI in the United States, Europe, and Japan every year. The purpose of this study is …
at UC Davis
Delivery Device for Administering LCTOPC1 in Participants with Spinal Cord Injury
Sorry, not yet accepting patients
The DOSED clinical study evaluates the safety and utility of a novel delivery device to deliver LCTOPC1, a cell therapy, to the spinal cord of patients with a spinal cord injury (SCI). LCTOPC1 is designed to replace or support cells that are absent…
at UCSD
Closed-loop Deep Brain Stimulation to Treat Refractory Neuropathic Pain
Sorry, in progress, not accepting new patients
Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but current technology is unable to reliably achieve long-term pain symptom relief. A "one-size-fits-all" approach of…
at UCSF
Decision Support Tool to Prevent Community-Acquired Pressure Injury in Spinal Cord Injury (SCI) in the Spinal Cord Injury Clinic
Sorry, not currently recruiting here
Spinal cord injury (SCI) is a permanent condition affecting every aspect of life including health, daily activities, and participation and quality of life. Persons with SCI are at high risk of pressure injury (PrI) throughout their lives due to loss …
at UCSD
Spinal Cord Neuromodulation for Spinal Cord Injury
Sorry, in progress, not accepting new patients
This study is designed to assess the strategy of using spinal cord stimulation to improve the ability to move in spinal cord injured humans.
at UCLA
MT-3921 in Subjects With Acute Traumatic Cervical Spinal Cord Injury
Sorry, in progress, not accepting new patients
The purpose of this study is to compare the efficacy and safety of intravenous (IV) infusions of MT-3921 to placebo in subjects with acute traumatic cervical spinal cord injury. Subjects meeting eligibility criteria will enter the 6-month…
at UC Irvine
Telepsychology in Spinal Cord Injury
Sorry, in progress, not accepting new patients
This study will determine the effectiveness of tele-psychology in treating persons with spinal cord injury (SCI) with depressed mood in the early period post-rehabilitation discharge. Depression among individuals with SCI is the most common…
at UCSF
Transforming Research and Clinical Knowledge in Spinal Cord Injury
Sorry, accepting new patients by invitation only
The overall goal of Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI) study is to determine the relationships among the clinical, neuroimaging, cognitive, genetic and proteomic biomarker characteristics of acute…
at UCSF
Our lead scientists for Spinal Cord Injury research studies include Karunesh Ganguly, MD, PhD Sergey Stavisky, Ph.D. Michael Su, MD Julian Motzkin Anthony DiGiorgio, MD Prasad Shirvalkar Edward Chang, M.D. Michael S Beattie, PhD Daniel C. Lu, MD, PhD.
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