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Spinal Deformity clinical trials at UC Health

5 in progress, 1 open to eligible people

Showing trials for
  • Tranexamic Acid to Reduce Blood Loss in Spine Trauma Surgery

    open to eligible people ages 18-75

    This study is designed to evaluate the efficacy of topical tranexamic acid to reduce perioperative blood loss, reduction in postoperative drain output and allogenic transfusion requirements. The proposed study will be a prospective, randomized, double-blind (subject, surgeons, investigators, research coordinators) placebo-controlled study. Patients following high energy trauma who have sustained thoracic or lumbar spine fractures, dislocations or ligamentous injury with resultant instability requiring posterior spinal fusion will be enrolled for this study. Furthermore, patients undergoing elective complex deformity surgery will also be enrolled. Both populations of patients will be randomized into two groups. Group I will receive standard of care operative fixation with topical tranexamic acid intervention (test); Group II will receive standard of care operative fixation with normal saline (placebo) intervention. This study will have a 2-year follow-up and will consist of three periods: screening/enrollment phase up to 21 days from the day of injury to the day of randomization and operative intervention, an inpatient data collection period for 4 days postoperative, and then a follow-up period for 2-years postoperative (visits occurring at 2 week, 16 week, 1 year, and 2 year) time points.

    at UCSF

  • Complex Adult Deformity Surgery

    Sorry, not currently recruiting here

    Evaluate surgical treatment outcomes and identify best practice guidelines for complex adult spinal deformity (ASD) patients, including radiographic and clinical outcomes, surgical and postoperative complications, risk factors for and revision surgery rates, and the role of standard work to improve patient outcomes and reduce surgical and postoperative complications.

    at UC Davis UCSF

  • Prospective Evaluation of Elderly Deformity Surgery

    Sorry, in progress, not accepting new patients

    As the population continues to age, the prevalence of spinal deformity surgery for older patients is increasing. Questions regarding the suitability of these patients to undergo large spinal procedures and whether the outcomes merit the risks involved are not well known.

    at UCSF

  • Prospective, Multi-Center Adult Spinal Deformity Outcomes Database Registry

    Sorry, in progress, not accepting new patients

    The clinical, radiographic, and HRQL outcomes will be compared in operative and nonoperative adult spinal deformity patients.

    at UC Davis UCSF

  • Spinal Deformity Intraoperative Monitoring.

    Sorry, not currently recruiting here

    A multicenter, international prospectively collected patient cohort undergoing high-risk spinal cord level surgery or spinal osteotomy procedures will be enrolled to establish the incidence of intraoperative alerts in high-risk spinal cord cases, and explore factors associated with mitigating injury. Baseline, intraoperative, and postoperative characteristics, including demographics, radiological features, lower extremity motor score (LEMS), procedure, anesthetic agents used, and baseline blood pressure will be recorded for either adult patients or pediatric patients.

    at UCSF

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