Stillbirth clinical trials at University of California Health

The primary objective of the Stillbirth Research Consortium (SBRC) longitudinal cohort study is to develop and evaluate a robust multivariable prediction model to identify pregnancies at <14 weeks gestation that are at increased risk of stillbirth or fetal growth restriction (FGR), often reflecting underlying placental dysfunction. Secondary objectives include: - To evaluate placental pathology among cases and selected controls using standardized Amsterdam criteria. - To identify key aspects of perinatal nutrition contributing to placental dysfunction - To determine relationships between maternal biomarkers, placental pathology and energetics, with the goal of identifying biomarkers predictive of placental dysfunction - To develop a risk stratification model for pregnancies complicated by decreased fetal movements (DFM)