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Surgery clinical trials at UC Health
6 in progress, 4 open to eligible people

  • A Study of the Accuracy of Experimental "Pulse CO-Oximetry" Technology for Noninvasive Hemoglobin (SpHb) Measurements

    open to eligible people ages 18 years and up

    This protocol is a request from Masimo to assist in the collection of data to be used to further refine the accuracy of the monitor's algorithm.

    at UC Davis

  • Multicenter Phase II Study of Transanal TME (taTME)

    open to eligible people ages 18 years and up

    Radical rectal cancer resection, namely total mesorectal excision (TME), is the cornerstone of the treatment of resectable rectal cancer. In combination with chemotherapy and radiation treatment (CRT), complete TME with negative resection margins is associated with sustained local and systemic control even in locally advanced disease. Over the last 2 decades, laparoscopic and robotic techniques have been increasingly adopted due to reduced surgical trauma and faster patient recovery. Yet, both approaches are associated with equivalent postoperative morbidity and disturbances in sexual, urinary and defecatory function relative to open TME. Furthermore, laparoscopic and robotic TME remain associated with substantial conversion rates and variable rates of TME completeness as a result of the procedural difficulties reaching the low rectum from the abdominal approach. Transanal TME (taTME) with laparoscopic assistance was developed to facilitate completion of TME using a primary transanal endoscopic approach. Transanal TME uses a "bottom-up approach" to overcome the technical difficulties of low pelvic dissection using an abdominal approach. Published results from single-center taTME series and an international registry suggest the short-term procedural and oncologic safety of this approach in resectable rectal cancer. No multicenter phase II study has yet been conducted to validate the procedural safety, functional outcomes or long-term oncologic outcomes of this approach. Study Design: This is a 5-year phase II multicenter single-arm study to evaluate the safety and efficacy of low anterior resection (LAR) with taTME using laparoscopic or robotic assistance in 100 eligible subjects with resectable rectal cancer. Hypothesis: taTME is non-inferior to standard LAR with respect to the quality of the TME achieved.

    at UC Irvine

  • Study looking at portable handheld device connected to a sensor that monitors blood oxygen levels when given IV fluid

    “Experimental device to non-invasively monitor oxygen in blood”

    open to eligible people ages 18 years and up

    This is a prospective, randomized, sequential data collection study to evaluate the ability of pleth variability index (PVI) to predict fluid responsiveness in comparison with other dynamic parameters including pulse pressure variation (PPV) and stroke volume variation (SVV).

    at UC Davis

  • Study to examine if video self review of intubation skills by medical students help them learn the skill faster

    “Video of medical students performing intubation on patients to aid in their education and competency of this skill”

    open to all eligible people

    This study is designed to evaluate the impact of a video recording review on the acquisition of a new technical skill (laryngoscopy and tracheal intubation).

    at UC Davis

  • Effect of Lost Wage Reimbursement to Kidney Donors on Living Donation Rates

    Sorry, in progress, not accepting new patients

    The study is designed as a randomized controlled trial. The investigators hypothesize that kidney transplant recipient candidates whose donors are offered reimbursement of lost wages (treatment arm) will have a higher probability of receiving a living donor kidney transplant than those randomized to no offer of lost wage reimbursement (control arm). The study expects to demonstrate incremental living donor kidney transplants by assisting individuals who wish to be living organ donors but would be otherwise unable to do so due to the obligatory forfeit of income during the evaluation, donation surgery, and post-operative recuperation periods.

    at UCLA

  • IPACK and Adductor Canal Catheter Patient Outcomes for TKAs?

    Sorry, not yet accepting patients

    This study evaluates the addition of the IPACK block to the adductor canal block and catheter in the pain management of total knee arthroplasty. Half of participants will receive the adductor canal block and catheter with the IPACK block, while the other half will receive the adductor canal block and catheter only.

    at UCLA

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