Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at UCLA
Dates
study started
completion around
Principal Investigator
by Veena K. Ranganath, MD, MS (ucla)
Headshot of Veena K. Ranganath
Veena K. Ranganath

Description

Summary

This is a Rheumatoid Arthritis (RA) study. The purpose of this research study is to determine in RA flare, whether musculoskeletal ultrasound (MSUS) inflammatory scores and/or disease activity scores improve with Acthar treatment.

Official Title

Use of Acthar in Rheumatoid Arthritis Related Flares

Details

Participants with active RA flair will be assigned to take on one of two Acthar doses, either 40 units per week or 80 units twice a week. Both arms will be taking the drug for 4 weeks. Each participant will be coming back for visits at 2 weeks, 1 month and 3 months after the initial baseline visit. During these visits the following information will be collected: MSUS of joints, DAS28, Clinical Disease Activity Index (CDAI), Routine Assessment of Patient Index Data 3 (RAPID3) and Health Assessment Questionnaire-Disability Index (HAQ-DI). Participants will also be asked to fill out a questionnaire about their health status.

Efficacy of Acthar to decrease evidence of MSUS synovitis and disease activity measures will be analyzed using the above mentioned instruments, as well as Acthar's ability to prevent the necessity to change patients' RA treatment regimen.

Keywords

Rheumatoid Arthritis (RA), Musculoskeletal ultrasound (MSUS), Arthritis, Rheumatoid Arthritis, Adrenocorticotropic Hormone, Acthar

Eligibility

Location

  • UCLA David Geffen School of Medicine, Division of Rheumatology accepting new patients
    Los Angeles California 90095 United States

Lead Scientist at University of California Health

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Veena Ranganath, MD, MS
ID
NCT02541955
Phase
Phase 4 research study
Study Type
Interventional
Participants
Expecting 40 study participants
Last Updated