Summary

for people ages 21-45 (full criteria)
healthy people welcome
at UCLA
study started
estimated completion:
Holly R Middlekauff (ucla)

Description

Summary

Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, and sham control, on sympathetic nerve activity and markers of oxidative stress.

Official Title

The Effects of Electronic Cigarettes on Sympathetic Nerve Activity and Oxidative Stress

Details

Participants will use an electronic cigarette on 3 occasions: 1) with nicotine, 2) without nicotine, 3) sham control, and measures of autonomic tone, including heart rate variability (HRV) and sympathetic nerve activity (MSNA: microneurography), and oxidative stress will be measured pre and post exposure.

Keywords

Nicotine Dependence nicotine autonomic tone oxidative stress Tobacco Use Disorder one time exposure to e-cig with nicotine One time exposure to e-cigarette without nicotine one time exposure to empty e-cigarette

Eligibility

You can join if…

Open to people ages 21-45

Healthy

You CAN'T join if...

  • Cardiac disease
  • Respiratory disease
  • Diabetes mellitus

Location

  • UCaliforniaLA accepting new patients
    Los Angeles California 90095 United States

Lead Scientist

  • Holly R Middlekauff (ucla)
    Professor, Medicine. Authored (or co-authored) 95 research publications

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, Los Angeles
ID
NCT02724241
Study Type
Interventional
Last Updated