Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at UCSF
Dates
study started
completion around

Description

Summary

Voided urinary cytology (VUC) is the most widely used urine-based assay for detecting bladder cancer (BCa); however, it fails to detect approximately 50% of low-grade or early stage BCa when it is most curable. Furthermore, the detection rate of VUC for recurrent BCa is not much better. Because of this severe limitation, all patients who are under surveillance to monitor for recurrent BCa must undergo an invasive examination of the urinary bladder, where a miniature camera is inserted into the bladder and the bladder inspected (cystoscopy). We propose to improve the non-invasive detection of recurrent BCa by further validating a multiplex ELISA assay directed at a BCa-associated diagnostic signature in voided urine samples.

Keywords

Bladder Cancer, Urinary Bladder Neoplasms

Eligibility

Locations

  • University of California San Francisco
    San Francisco California 94158 United States
  • Cedars-Sinai Medical Center
    Los Angeles California 90048 United States
  • UT Southwestern Medical Center at Dallas
    Dallas Texas 75390 United States
  • Kyoto University Graduate School of Medicine
    Kyoto Japan

Details

Status
in progress, not accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Cedars-Sinai Medical Center
ID
NCT03193515
Study Type
Observational
Participants
About 300 people participating
Last Updated