for people ages 21 years and up (full criteria)
Healthy Volunteers
healthy people welcome
study started
estimated completion



This project will examine the impact of very low nicotine content (VLNC) cigarettes in a complex tobacco and nicotine product marketplace. We will compare the number of cigarettes smoked and cigarette-free days in an experimental marketplace that contains VLNC cigarettes versus normal nicotine content (NNC) cigarettes.

Official Title

Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace Part of "Evaluating New Nicotine Standards for Cigarettes"


This randomized, open label, controlled, multi-site study will simulate a "real world" tobacco environment by providing participants access to an experimental marketplace where they will be given vouchers for a specified number of points that can be exchanged for study cigarettes (varying in nicotine content described below) and non-combusted tobacco/nicotine products (smokeless tobacco, snus, electronic cigarette, medicinal nicotine replacement) and at the end of the study can exchange unspent points for money. Subjects (N=200 in each group) will be randomly assigned to: 1) very low nicotine content cigarettes (VLNC; 0.4 mg/g) along with non-combusted tobacco/nicotine products or 2) normal nicotine content cigarettes (NNC; 15.8 mg/g) along with non-combusted tobacco/nicotine products. Smokers will undergo an orientation visit for screening and then enter a three phase experimental trial: 1. Phase 1 - Baseline: Two week baseline assessment period during usual brand cigarette smoking. 2. Phase 2 - Marketplace Adaptation: Two week period where subjects have access to the marketplace that provides their preferred usual brand cigarettes and selected non-combusted tobacco products to allow the subject to adjust to the marketplace prior to randomization; 3. Phase 3 - Intervention: Randomization to a marketplace with access to either VLNC or NNC cigarettes plus non-combusted products for a 12 week period. Biomarker samples are collected at baseline, end of Phase 2 and end of week Phase 3 (week 12).


Tobacco Smoking Nicotine Dependence Reduced nicotine cigarettes Alternative nicotine products Biomarkers of tobacco exposure Tobacco Use Disorder Nicotine Very Low Nicotine Content Cigarettes Normal Nicotine Content Cigarettes


You can join if…

Open to people ages 21 years and up

  1. Male or female;
  2. At least 21 years of age;
  3. Biochemically confirmed smoker.

You CAN'T join if...

  1. Unstable health condition;
  2. Unstable medications;

d) Pregnant or nursing.


  • Tobacco Research Center accepting new patients
    San Francisco California 94110 United States
  • Tobacco Research Programs accepting new patients
    Minneapolis Minnesota 55414 United States


accepting new patients
Start Date
Completion Date
University of Minnesota
Phase 3 research study
Study Type
Expecting 400 study participants
Last Updated