This study is in progress, not accepting new patients

Brain Function in Adolescent Eating Disorders and Healthy Peers

a study on Eating Disorders

Summary

Eligibility
for females ages 14-17 (full criteria)
Healthy Volunteers
healthy people welcome
Location
at UCSD
Dates
study started
study ends around
Principal Investigator
by Christina Wierenga (ucsd)
Headshot of Christina Wierenga
Christina Wierenga

Description

Summary

This study of adolescent eating disorders (ED) will examine the association of temperament-based classifications, brain activation during incentive processing, and ED symptoms at time of scan and 1 year later to better understand the neurobiology and symptoms of ED. We will recruit 150 females currently ill with an ED and 50 controls ages 14-17 to investigate how temperaments reflecting greater inhibition, impulsivity, or effortful control correspond to 1) clinical symptoms and 2) the brain's response to anticipation and outcome of salient stimuli, and 3) by collecting follow-up clinical data one year later, identify how temperament-based subtypes predict ED symptom change (e.g., clinical prediction). Data collection will rely on a technology called functional magnetic resonance imaging (fMRI).

Official Title

Neurocircuitry of Temperament and Motivated Behavior in Adolescent Eating Disorders

Keywords

Eating Disorder, adolescents, healthy controls, Feeding and Eating Disorders

Eligibility

You can join if…

Open to females ages 14-17

  • Female
  • Meet DSM-V criteria for an Eating Disorder or Never met criteria for an Eating disorder
  • Medically stable
  • Post-Pubertal (must have started menses, but subsequent loss of menses secondary to ED is fine).

You CAN'T join if...

  • Psychotic illness/other mental illness requiring hospitalization
  • Current dependence on drugs or alcohol
  • Physical conditions known to influence eating or weight (e.g, diabetes mellitus, pregnancy).
  • On psychoactive medication
  • Organic brain syndromes, delirium, psychotic disorders, or intellectual disability
  • Neurological or medical disorders such as seizure disorder
  • Any contraindication to undergoing an MRI
  • Major depressive disorder
  • Left handed

Location

  • University of California San Diego
    San Diego 5391811 California 5332921 92121 United States

Lead Scientist at University of California Health

  • Christina Wierenga (ucsd)
    Christina Wierenga, Ph.D., is a Professor and Clinical Neuropsychologist in the Department of Psychiatry at the University of California San Diego. She is a Fellow of Division 40 (Neuropsychology) of the American Psychological Association (APA), a Fellow of the Academy of Eating Disorders and a Member of the Eating Disorders Research Society.

Details

Status
in progress, not accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Diego
ID
NCT03347565
Study Type
Observational
Participants
About 155 people participating
Last Updated