for people ages 18 years and up (full criteria)
study started
estimated completion



This is a phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to evaluate the efficacy and safety of CSL112 on reducing the risk of major adverse CV events [MACE - cardiovascular (CV) death, myocardial infarction (MI), and stroke] in subjects with acute coronary syndrome (ACS) diagnosed with either ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation myocardial infarction (NSTEMI), including those managed with percutaneous coronary intervention (PCI) or medically managed.

Official Title

A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Investigate the Efficacy and Safety of CSL112 in Subjects With Acute Coronary Syndrome


Acute Coronary Syndrome Syndrome Apolipoprotein A-I [human] (apoA-I) CSL112


You can join if…

Open to people ages 18 years and up

  • Male or female least 18 years of age
  • Evidence of myocardial necrosis, consistent with type I (spontaneous) MI
  • No suspicion of acute kidney injury
  • Evidence of multivessel coronary artery disease
  • Presence of established cardiovascular risk factor(s):
  • Diabetes mellitus on pharmacotherapy OR
  • 2 or more of the following: age ≥ 65 years, prior history of MI, peripheral arterial disease

You CAN'T join if...

  • Ongoing hemodynamic instability
  • Evidence of hepatobiliary disease
  • Evidence of severe chronic kidney disease
  • Plan to undergo scheduled coronary artery bypass graft surgery as treatment for the index MI
  • Known history of allergies, hypersensitivity, or deficiencies to soy bean, peanut or albumin


  • 8400693 - University of California Los Angeles accepting new patients
    Los Angeles California 90038 United States
  • 8400694 - University of California San Diego Medical Center in progress, not accepting new patients
    San Diego California 92103 United States
  • 8400719 - V.A. San Diego Health Care System in progress, not accepting new patients
    San Diego California 92161 United States
  • 8400745 - Hoag Memorial Hospital Presbyterian in progress, not accepting new patients
    Newport Beach California 92663 United States
  • 8401103 - Orange Coast Memorial Hospital accepting new patients
    Fountain Valley California 92708 United States
  • 8400703 - San Diego Cardiac Center accepting new patients
    San Diego California 92123 United States
  • 8401192 - South Orange County Surgical Medical Group accepting new patients
    Laguna Hills California 92653 United States
  • 8400888 - Saint Jude Heritage Healthcare accepting new patients
    Mission Viejo California 92691 United States


accepting new patients
Start Date
Completion Date
CSL Behring
Phase 3
Study Type
Last Updated