for people ages 50 years and up (full criteria)
study started
estimated completion
Principal Investigator
by SriniVas Sadda (ucla)



The investigators wish to better understand the role of the choriocapillaris (CC) in the formation and progression of non-exudative in age related macular degeneration (armd) by imaging the retinal pigment epithelium (rpe) and the choroidal microvasculature and by studying their inter-dependence to determine if the loss of the CC could prove useful as an anatomic clinical trial endpoint in future drug trials.

Official Title

Non Exudative Age-Related Macular Degeneration Imaged With Swept Source Optical Coherence Tomography


This is a longitudinal observational study where the investigators will look at 450 subjects, 200 with intermediate AMD in at least one eye, or with AMD in one eye, either early or intermediate, and with late AMD (exudative) in the other eye, and 250 subjects with nGA or GA in at least one eye.


Dry Macular Degeneration AMD early AMD intermediate AMD Geographic Atrophy nascent GA Macular Degeneration SS-OCT imaging


You can join if…

Open to people ages 50 years and up

  1. Aged 50 and over
  2. Clinic diagnosis of non-exudative iAMD in at least one eye with a drusen volume in the central 3 mm circle centered on the fovea of at least 0.02 mm3 in the absence of GA or nGA as diagnosed with OCT en face imaging OR Clinical diagnosis of early or early/intermediate stage AMD in one eye in the absence of nGA or GA and exudative AMD in the other eye OR clinical diagnosis of GA or nGA secondary to AMD that is at least the size of a large druse (125 microns in diameter; 0.05 mm2) and no greater than 7 disc areas (17 mm2) in at least one eye which has never been treated with anti-VEGF agents
  3. Willing and able to comply with clinic visits and study-related procedures
  4. Provide signed informed consent

You CAN'T join if...

A subject who meets any of the following criteria will be excluded from the study:

  1. Below the age of 50
  2. Subjects with exudative AMD in both eyes
  3. Eyes with evidence of non-proliferative and proliferative diabetic retinopathy.
  4. Presence of confounding ocular diagnosis such as myopia >6D, or other ocular conditions that may cause retinal pigment epithelium atrophy or exudative MNV
  5. Subjects unable to give informed consent.
  6. Subjects who are unable to comply with imaging guidelines


  • University of California Los Angeles Doheny Eye Institute accepting new patients
    Los Angeles California 91105 United States
  • Bascom Palmer Eye Institue accepting new patients
    Miami Florida 33136 United States

Lead Scientist at University of California Health


accepting new patients
Start Date
Completion Date
Boston Image Reading Center
Study Type
Last Updated