Smoking and Ventricular Repolarization

a study on Cardiac Arrest Prolonged QTc Interval Nicotine

Summary

Eligibility
for people ages 21-45 (full criteria)
Healthy Volunteers
healthy people welcome
Location
at UCLA
Dates
study started
estimated completion
Principal Investigator
by Holly R Middlekauff, MD (ucla)

Description

Summary

Randomized controlled trial of acute use of electronic cigarette or tobacco cigarette on parameters of ventricular repolarization.

Details

Non-user or chronic electronic cigarette (EC) users will use an EC or control on three occasions:1) EC with nicotine, 2) EC without nicotine, 3) empty EC (control).

Chronic tobacco cigarette (TC) smokers will use a TC or control on three occasions: 1) TC with nicotine (subject's own brand), 2) research TC with very low nicotine, 3) straw (control). The electrocardiogram will be recorded before and after acute exposures and analyzed for parameters representative of ventricular repolarization.

Keywords

Sudden Cardiac Death, Prolonged QTc Interval, e-cigarettes, tobacco cigarettes, nicotine, ventricular repolarization, Death, Sudden, Cardiac, Death, EC with nicotine, EC without nicotine, TC with nicotine (own brand), research TC with very low level nicotine, Chronic EC user, Chronic TC smoker

Eligibility

You can join if…

Open to people ages 21-45

- Healthy non-smokers chronic TC smokers (non-e-cig users) Chronic EC smokers (Non-TC smokers)

You CAN'T join if...

- Cardiac disease, respiratory disease, diabetes

Location

  • UCaliforniaLA accepting new patients
    Los Angeles California 90095 United States

Lead Scientist at University of California Health

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, Los Angeles
ID
NCT03916341
Study Type
Interventional
Participants
Expecting 145 study participants
Last Updated