Summary

for people ages 18-65 (full criteria)
at UCSD
study started
estimated completion
Albert Leung, M.D.(ucsd)

Description

Summary

This study aims to look at the long term efficacy of using repetitive transcranial magnetic stimulation (rTMS) in relieving Gulf War Illness related headaches and pain.

Details

Headaches (HA), muscle and joint pain, are some of the most common debilitating symptoms in military personnel served in the 1990-1991 Persian Gulf War (GW1). Migraine like HA and diffuse body pain were detected in 64% of Gulf War Veteran (GWV) diagnosed with Gulf War Illness (GWI). Unfortunately, conventional pharmacological treatments for GWI-related pain has not been shown to be effective and drugs such as narcotics contain many long term untoward psychosomatic and abusive side effects. This study is assessing the effectiveness of repetitive transcranial magnetic stimulation (rTMS), non-invasive treatment option, in alleviating headaches, muscle, and joint pain symptoms of GWI.

Keywords

Gulf War Syndrome Gulf War Illness Headache Muscle Pain Joint Pain rTMS Transcranial Magnetic Stimulation Arthralgia Myalgia Persian Gulf Syndrome

Eligibility

You can join if…

Open to people ages 18-65

  • Male or female under 65 years of age who served in the military for at least 30 consecutive days between August 1, 1990, and July 31, 1991 in the Persian Gulf War region
  • Center for Disease Control (CDC) Criteria for Gulf War Illness (GWI)
  • Kansas Criteria for GWI
  • International Headache Society Criteria for Migraine Headache without aura Average Headache Exacerbation Intensity >3 on 0-10 a Numerical Pain Rating scale (NPS)
  • Average Overall Daily Muscle Pain Intensity >3 on 0-10 a NPS
  • Average Overall Daily Extremities Joint Pain Intensity >3 on 0-10 a NPS
  • Headache Exacerbation/attack 3 times per week with the average intensity >3 on a 0-10 NPS, lasting > 4 hours in the past three months
  • Hamilton Rating Scale of Depression (HRSD) <14 based on the sum of scores for the first 17 items

You CAN'T join if...

  • Pregnancy
  • History of pacemaker implant
  • Any ferromagnetic (e.g. bullet fragment, shrapnel, device implant) in the brain or body that will prohibit the patients from having a brain MRI
  • History of dementia, major psychiatric diseases, or life-threatening diseases
  • Presence of any other chronic neuropathic pain states such as Complex Regional Pain Syndrome or Painful Peripheral Neuropathy
  • History of seizure
  • Pending litigation
  • Low back pain with mechanical origins such as lumbar radiculopathy or radiculitis or lumbar facet arthropathy
  • Lack of ability to understand the experimental protocol and to adequately communicate in English
  • History of Traumatic Brain injury
  • Chronic Tension or Cluster Headache
  • Ongoing Cognitive Rehabilitation or Treatment of PTSD

Locations

  • VA San Diego Healthcare System accepting new patients
    San Diego California 92161 United States
  • VA Palo Alto accepting new patients
    Palo Alto California 94304 United States

Lead Scientist

  • Albert Leung, M.D. (ucsd)
    Clinical Professor, Anesthesiology. Authored (or co-authored) 22 research publications

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Veterans Medical Research Foundation
ID
NCT04182659
Study Type
Interventional
Last Updated