Summary

Eligibility
for females ages 35-50 (full criteria)
Location
at UC Davis UCLA UCSF
Dates
study started
completion around
Principal Investigator
by Beth Y. Karlan, MD (ucla)
Headshot of Beth Y. Karlan
Beth Y. Karlan

Description

Summary

This clinical trial evaluates how well two surgical procedures (bilateral salpingectomy and bilateral salpingo-oophorectomy) work in reducing the risk of ovarian cancer for individuals with BRCA1 mutations. Bilateral salpingectomy involves the surgical removal of fallopian tubes, and bilateral salpingo-oophorectomy involves the surgical removal of both the fallopian tubes and ovaries. This study may help doctors determine if the two surgical procedures are nearly the same for ovarian cancer risk reduction for women with BRCA1 mutations.

Official Title

A Non-Randomized Prospective Clinical Trial Comparing the Non-Inferiority of Salpingectomy to Salpingo-oophorectomy to Reduce the Risk of Ovarian Cancer Among BRCA1 Carriers [SOROCk]

Details

Keywords

Ovarian Carcinoma, Bilateral Salpingectomy, Bilateral Salpingectomy with Oophorectomy, Biospecimen Collection, Quality-of-Life Assessment, Transvaginal Ultrasound, Ultrasound Imaging, bilateral salpingo-oophorectomy

Eligibility

Locations

Lead Scientist at University of California Health

  • Beth Y. Karlan, MD (ucla)
    Department Vice Chair, Pediatrics, Medicine. Authored (or co-authored) 381 research publications

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
NRG Oncology
ID
NCT04251052
Study Type
Interventional
Participants
Expecting 2262 study participants
Last Updated