Summary

Eligibility
for people ages 65 years and up (full criteria)
Healthy Volunteers
healthy people welcome
Location
at UCLA
Dates
study started
estimated completion
Principal Investigator
by Zhaoping Li (ucla)

Description

Summary

Many elderly experience weight loss and weakness with normal aging. Although there is extensive literature regarding nutritional advice for the elderly, there are few well- designed studies evaluating the effect of oral nutrition supplements in patients with weight loss and aging. The aim of this study is to examine the effect of dietary prescription with or without nutrition supplementation that includes soy protein, whey protein and fish oil in elderly patients who have suffered unintentional weight loss.

Details

This is an 8-week, randomized, pilot study with elderly subjects (age 65 and older) with recent unintentional weight loss who will receive either two servings of supplement powder and fish oil or no dietary supplementation (N=10 for each group).

Keywords

Sarcopenia Elderly protein supplementation unintentional weight loss Weight Loss Protein shake + Fish Oil Supplement + Fish Oil

Eligibility

You can join if…

Open to people ages 65 years and up

  • Male or female age 65 and older
  • Non-smokers
  • Weight loss >3% body weight over 6-12 months
  • BMI ≤ 25
  • Living independently or in an assisted living facility

You CAN'T join if...

  • Medical conditions that would lead to weight loss
  • Active cancer undergoing treatment (chemotherapy, radiation therapy, or planned surgical intervention)
  • CKD stage IV-V (eGFR <30) based on medical records within the last 12 months
  • Presence of dysphagia or odynophagia
  • Actively taking blood thinner such as Warfarin
  • Known history of cirrhosis with presence of ascites
  • History of a surgical procedure for weight loss (e.g. gastroplasty, gastric bypass, gastrectomy or partial gastrectomy, lap-band)
  • Any abnormal lab findings outside of normal limits as determined by the investigator
  • Dietary conditions
  • Diet restrictions including vegetarianism, veganism, soy-free diet,
  • Fish and/or fish oil allergy or intolerance
  • Milk allergy excluding lactose intolerance
  • Follows a kosher diet
  • Medications
  • Use of appetite stimulants (including megestrol, dronabinol and cyproheptadine).
  • Does not include medications used for depression (e.g. mirtazapine, paxil) if patient has been on a stable dose of this medication for at least 3 months prior to the start of this study
  • If participant is already taking a fish oil supplement, he/she must be willing to either stop the supplement or take the supplement the investigators are using in the study depending on the randomization assignment
  • Additional
  • Patient has implantable device such as a pacemaker or ICD
  • Unable to complete 6-minute walk test at baseline
  • Hospitalization within the last 30 days
  • Participation in a therapeutic research study within 30 days of baseline
  • Living in a skilled nursing facility or long-term care facility
  • Any other medical condition that principal investigator or co-investigators deem would preclude the patient from study participation

Location

  • UCLA Center for Human Nutrition, 1000 Veteran Ave. accepting new patients
    Los Angeles California 90095 United States

Lead Scientist at UC Health

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, Los Angeles
ID
NCT04350762
Study Type
Interventional
Last Updated