for females ages 18-40 (full criteria)
Healthy Volunteers
healthy people welcome
at UC Irvine
study started
estimated completion
Principal Investigator
by Karen Lindsay (uci)



This study will investigate how maternal emotional state following a controlled stress exposure in pregnancy influences blood glucose and insulin levels after eating a standardized meal, and whether the effects of emotional state on blood glucose and insulin is different after eating a healthy meal (low GI) compared to a less healthy meal (high GI).

Official Title

Postprandial Response to Emotion-Diet Interactions in Pregnancy


Maternal glucose-insulin homeostasis in pregnancy represents one of the most important physiological processes for maternal and child health outcomes. Although maternal diet is a key regulator of this process, its effects vary widely across individuals. Maternal stress could represent a moderator of considerable importance in this regard, yet little is known about the effects of stress on glycemic control in pregnancy and whether the effects of stress may vary as a function of diet quality. This project will investigate the effects of acute psychosocial stress exposure on the postprandial metabolic response to a meal of varying glycemic index (GI) among women with overweight/obesity in mid-pregnancy.


Pregnancy Related, Stress, Psychological, Glucose Intolerance During Pregnancy, Emotional Stress, Postprandial Hyperglycemia, Insulin Sensitivity/Resistance, Insulin Resistance, Hyperglycemia, Glucose Intolerance, Psychological Stress, Psychosocial stress


You can join if…

Open to females ages 18-40

  • English and/or Spanish speaking
  • 18-22 week's gestation
  • Pre-pregnancy BMI 25.0-39.9 kg/m2
  • Singleton, intrauterine pregnancy
  • Non-smoker
  • Non-diabetic and normal result on a random peripheral blood glucose test at the screening visit (<200 mg/dl)

You CAN'T join if...

  • Non-fluency in English or Spanish
  • BMI <25.0 or ≥40.0 kg/m2
  • >22 week's gestation
  • multiple pregnancy
  • current smoker
  • present/prior obstetric conditions (preeclampsia, infections, placental abnormalities, uterine anomalies, congenital malformations, fetal chromosomal abnormalities)
  • presence of any conditions that may dysregulate neuroendocrine, metabolic or cardiovascular function, such as diabetes, hepatic, renal, or autoimmune disorders
  • current psychiatric disorders or undergoing treatment/taking psychiatric medications
  • use of systemic/frequent corticosteroids or thyroid, lipid-lowering or anti-diabetic medications
  • gestational diabetes mellitus or raised glucose result detected on the screening visit
  • unwilling to eat the standard breakfast meal at each laboratory visit


  • University of California, Irvine accepting new patients
    Irvine California 92617 United States
  • UCI Medical Center, University of California, Irvine accepting new patients
    Orange California 92868 United States

Lead Scientist at University of California Health

  • Karen Lindsay (uci)
    Assistant Professor, Pediatrics, School of Medicine. Authored (or co-authored) 48 research publications


accepting new patients
Start Date
Completion Date
University of California, Irvine
Study Type
Expecting 80 study participants
Last Updated