Summary

Eligibility
for people ages 18-85 (full criteria)
Location
at UCSF
Dates
study started
estimated completion
Principal Investigator
by Ying Han, MD, PhD (ucsf)Thuy Doan, MD, PhD (ucsf)
Photo of Ying Han
Ying Han
Photo of Thuy Doan
Thuy Doan

Description

Summary

In this study, the investigators seek to determine the effect of antibiotic use post-surgery on antimicrobial resistance. The investigators will be studying adults (aged 18 or older) who will undergo eye surgery at University of California, San Francisco (UCSF). We seek to gain a better understanding of how antibiotic use during the perioperative period influences local and systemic antibiotic resistance at the individual level.

Official Title

Antibiotic Resistance In Eye Surgeries (ARIES)

Details

Antibiotic use has saved millions of lives globally. However, this comes at the cost of selecting for antibiotic-resistant organisms at the individual and the community level. It is estimated that every year, approximately 700,000 deaths are associated with drug resistance globally. This places a significant burden on the public health system and the judicious use of antibiotics is more important than ever before. The proposed masked, randomized controlled trial evaluates the effects of topical antibiotic use on the selection of antibiotic resistance determinants at the local and systemic levels. The results will provide guidance for antibiotic usage in ophthalmology and may have the potential to inform public health policies.

Keywords

Antibiotic Resistance Ocular Surface Microbiome Gut Resistome Moxifloxacin Moxifloxacin (Topical) Intraoperative antibiotics (Abx); Postoperative topical antibiotics four times a day for 1 week Intraoperative antibiotics (Abx); Postoperative topical antibiotics once a day for 1 week

Eligibility

You can join if…

Open to people ages 18-85

  1. Over 18 years of age
  2. Undergoing cataract surgeries that would benefit from intracameral antibiotics
  3. Able to provide swabs
  4. Able to provide consent
  5. Surgery of the second eye occurs at least 8 weeks after surgery of the first eye

You CAN'T join if...

  1. Same-day bilateral cataract surgeries
  2. On immunosuppression medication such as Prednisone, Methotrexate, Cellcept, or anti-TNF inhibitors within past 3 months
  3. On systemic antibiotic within past 3 months
  4. On topical antibiotics within past 8 weeks
  5. Allergies to fluoroquinolone
  6. Patients needing glaucoma drainage device or trabeculectomy
  7. Inability to consent

Location

  • University of California, San Francisco accepting new patients
    San Francisco California 94158 United States

Lead Scientists at University of California Health

  • Ying Han, MD, PhD (ucsf)
    Professor, Ophthalmology. Authored (or co-authored) 43 research publications.
  • Thuy Doan, MD, PhD (ucsf)
    Associate Professor, Proctor Foundation. Authored (or co-authored) 67 research publications.

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
ID
NCT04750655
Phase
Phase 4
Study Type
Interventional
Last Updated